In one of the deadliest human cancers, cheap nutraceuticals produced coordinated suppression of tumor proliferation, cancer hallmarks, immune checkpoints, stemness, and activated intrinsic apoptosis.
Glioblastoma (GBM) remains one of the most aggressive and lethal human cancers, with a median survival of roughly 15 months despite surgery, radiation, and chemotherapy. In a newly published paper in BJC Reports titled, Attenuation of malignant phenotype of glioblastoma following a short course of the pro-oxidant combination of Resveratrol and Copper, researchers found a short, non-toxic oral intervention that simultaneously suppresses tumor proliferation, cancer hallmarks, immune checkpoints, and stemness — while activating intrinsic tumor cell death.
In a small but carefully controlled pre-surgical “window” study, human glioblastoma patients received resveratrol (5.6 mg) plus copper (560 ng) four times daily for an average of just ~12 days before tumor resection. Tumor tissue was then compared with untreated controls.
The results reveal a system-level attenuation of malignant phenotype: near-eradication of tumor-promoting cell-free chromatin particles (cfChPs)—accompanied by a ~31% reduction in tumor proliferation (Ki-67), suppression of nine cancer hallmarks and cancer stemness, simultaneous down-regulation of six immune checkpoints, and activation of intrinsic apoptosis, all within ~12 days.
This was not a marginal signal. It was a coordinated, system‑level biological shift in one of the deadliest cancers known…
CONCLUSION
After ~12 days of a non-toxic oral intervention (resveratrol plus copper), glioblastoma tumors demonstrated:
- Near-elimination of tumor-promoting chromatin debris (cfChPs)
- A marked reduction in tumor cell proliferation (Ki-67)
- Suppression of nine core hallmarks of cancer
- Simultaneous down-regulation of six immune checkpoints
- Significant loss of cancer stem cell markers
- Large-scale reprogramming of tumor gene expression
- Activation of organized, intrinsic tumor cell death with efficient cleanup
Together, these findings indicate that a short, non-toxic intervention can biologically “de-escalate” one of the most aggressive human cancers across multiple independent axes of malignancy.
The authors explicitly note that longer trials are urgently needed to determine whether prolonged treatment could push tumors toward a more benign phenotype or improve clinical outcomes.
https://open.substack.com/pub/petermcculloughmd/p/new-study-resveratrol-and-copper