From the Cordyceps Mushroom

Given Cordycepin’s ability to downregulate NRP1 expression, it may warrant investigation as an adjunct therapy for Long COVID.

(Neuropilin 1 (NRP1) is a protein expressed by various cells in the body, including neurons, blood vessels, and immune cells. It binds to different types of extracellular ligands, influencing the development and functioning of organs. NRP1 is involved in signaling pathways, particularly in the brain and retina, and has potential as a target for therapeutics in the treatment of neovascular eye diseases.)

(A ligand is simply a molecule or ion that binds to a central entity—either a metal atom (in chemistry) or a receiving protein (in biology)—to form a larger complex. This binding triggers a specific chemical or physiological response.)

(In science, an ion is an atom or molecule that has a net electrical charge because it has gained or lost one or more electrons. Because they are electrically charged, ions play critical roles in everything from biological nerve impulses to battery technology.)

Finish reading: https://wmcresearch.substack.com/p/friday-hope-cordycepin-cd-from-the

From the Cordyceps Mushroom

Given Cordycepin’s ability to downregulate NRP1 expression, it may warrant investigation as an adjunct therapy for Long COVID.

(Neuropilin 1 (NRP1) is a protein expressed by various cells in the body, including neurons, blood vessels, and immune cells. It binds to different types of extracellular ligands, influencing the development and functioning of organs. NRP1 is involved in signaling pathways, particularly in the brain and retina, and has potential as a target for therapeutics in the treatment of neovascular eye diseases.)

(A ligand is simply a molecule or ion that binds to a central entity—either a metal atom (in chemistry) or a receiving protein (in biology)—to form a larger complex. This binding triggers a specific chemical or physiological response.)

(In science, an ion is an atom or molecule that has a net electrical charge because it has gained or lost one or more electrons. Because they are electrically charged, ions play critical roles in everything from biological nerve impulses to battery technology.)

Finish reading: https://wmcresearch.substack.com/p/friday-hope-cordycepin-cd-from-the

Quote of the Day

“Rest satisfied with doing well, and leave others to talk of you as they will.” – Pythagoras, Mathematician (582 – 497 BC)

Dawn Loggins

Dawn Loggins

It’s not so much the cards we are dealt as how we play the hand.

On the morning of Thursday, the seventh of June, 2012, in the gymnasium of Gardner-Webb University in Boiling Springs, North Carolina, approximately ten miles southwest of the town of Lawndale in northern Cleveland County, an eighteen-year-old graduating senior named Ashley Dawn Loggins walked across the stage to receive her diploma from Burns High School, where she had completed three Advanced Placement courses, an honors English course, and three years of consistent A and A-minus grades while working approximately twenty hours per week as a part-time custodian on the same school grounds. She had been admitted, four months earlier, to the entering class of two thousand sixteen of Harvard College in Cambridge, Massachusetts. She was, by the documented institutional records of Burns High School, the first student in the school’s history to be admitted to Harvard.

Dawn Loggins had been born in 1993 or 1994 and had been raised in Cleveland County and adjacent rural areas of western North Carolina by her mother and stepfather. The household had been characterized by serial economic instability and repeated relocations between rental properties and squatting arrangements. By Dawn Loggins’s documented later accounts in interviews with the Cable News Network, the American Broadcasting Company, the Columbia Broadcasting System, and the Seattle Times, the household at various periods of her childhood had lacked electricity, lacked running water, had been infested with cockroaches, and had been heated only by a wood-burning cook stove.

She and her older brother Shane had walked approximately twenty minutes each direction to a public park in their town of residence to fill water jugs at the public bathroom spigots, in periods when their household’s water service had been disconnected. She and her brother had performed their schoolwork by candlelight on evenings when the household’s electricity had been disconnected. She had, in middle school, often gone several days at a time without bathing.

By the time Dawn Loggins enrolled at Burns High School in Lawndale in March of 2010 at the midpoint of her sophomore year, she had attended four different high schools and had missed an academic year of instruction. Her guidance counselor at Burns High School, Robyn Putnam, identified her academic potential within several weeks of her enrollment. Putnam enrolled Dawn Loggins in remedial-credit courses to recover the missed academic year and advocated for her admission to a series of school extracurricular activities including the photography club, the rock climbing club, and the Spanish club, of all three of which Dawn Loggins was elected president during her junior year.

In the summer of 2011, Dawn Loggins was selected for the Governor’s School of North Carolina — a six-week residential summer program for academically gifted secondary students hosted that year at Meredith College in Raleigh. Robyn Putnam drove Dawn Loggins the approximately two hundred miles from Lawndale to Raleigh to deliver her to the program and purchased the personal clothing and supplies that the program required.

Near the conclusion of the six-week program, Dawn Loggins attempted to telephone her family residence in Lawndale. The household telephone service had been disconnected. When she returned to Lawndale at the program’s conclusion, the household was empty. Her brother Shane had relocated to friends’ homes in nearby Hickory. Her grandmother had been transferred to a local homeless shelter. Her parents had relocated to Tennessee without leaving a forwarding address or contact information. She subsequently learned, several months later, that they had decided to remain in Tennessee permanently. Dawn Loggins was seventeen years old.

She elected, in consultation with Robyn Putnam, to remain at Burns High School to complete her senior year rather than to relocate to Tennessee or to enter the North Carolina Department of Social Services foster care system. Sheryl Kolton, a custodian and bus driver for the Burns Middle School and the mother of one of Dawn Loggins’s high school friends, had met Dawn Loggins only briefly prior to the autumn of 2011, provided her with a permanent residence for the duration of her senior year. The arrangement had been originally proposed by Sheryl Kolton’s daughter, who had told her mother that Dawn Loggins had been couch-surfing among the homes of her high school friends since August of 2011 and that the arrangement was not sustainable for the senior academic year. Sheryl Kolton subsequently agreed to receive Dawn Loggins on a permanent basis through her June 2012 graduation.

Other Burns High School staff contributed to her expenses for clothing, medical care, and dental appointments. Dawn Loggins obtained, through a school workforce program, a part-time custodial position at Burns High School itself — beginning at six in the morning, two hours before her classes commenced at seven-forty.

During her senior year, Dawn Loggins maintained a three-point-nine grade point average across three Advanced Placement courses, an honors English course, and several other classes. She scored two thousand one hundred and ten on the Scholastic Aptitude Test. In December of 2011, on the recommendation of her history teacher Larry Gardner and a community volunteer named Carol Rose, she submitted her fifth college application — to Harvard College in Cambridge, Massachusetts. The four previous applications had been to the University of North Carolina at Chapel Hill, North Carolina State University, Davidson College, and Warren Wilson College. All four of the in-state applications had been accepted.

The Harvard admissions decision arrived at Burns High School in March of 2012 in a small envelope. Dawn Loggins was admitted to the Harvard College entering class of two thousand sixteen. The university subsequently confirmed that her financial aid package would cover the entirety of her tuition, room, board, and supplemental expenses for all four years of her undergraduate enrollment. Her brother Shane was awarded a full scholarship to Berea College in Kentucky for the same academic year.

Dawn Loggins graduated from Burns High School on the seventh of June, 2012. She enrolled at Harvard College that autumn.

Flash Shelton

Flash Shelton

When strangers moved into his mother’s house, the police told him there was little they could do.

So he moved in too.

What happened next turned Flash Shelton into one of the most unusual property defenders in America.

The story began during one of the most difficult periods of his life. After the death of his father, Shelton was helping his mother sell her vacant California home when he received shocking news: unknown people had taken over the property and were refusing to leave.

Like many homeowners who face squatters, he expected the situation to be resolved quickly.

Instead, he discovered a frustrating reality.

Because the occupants claimed certain tenant protections, law enforcement treated the dispute as a civil matter rather than a criminal one. The legal process could take months, sometimes even longer.

Most people would have hired a lawyer and waited.

Flash came up with a very different plan.

After studying the laws carefully, he realized that if the squatters were using tenancy rules to remain in the home, he could potentially use those same rules to get back inside.

With his mother’s permission, he established legal tenancy for himself, drove nearly 19 hours to the property, and patiently waited for an opportunity.

When the occupants left, Shelton entered the house, secured access points, installed cameras, and made himself at home.

The next time the squatters returned, they discovered something they had not expected.

Someone else was already living there. ????

And unlike them, he had the homeowner’s permission.

That experience eventually became the foundation of a business that earned him the nickname “Squatter Hunter.”

Instead of relying solely on lengthy court battles, Shelton developed a strategy centered on lawful occupancy and constant presence. His team moves into disputed properties with the homeowner’s approval and remains there until unwanted occupants decide to leave voluntarily.

Music plays.

Common areas are occupied.

The property is actively used.

In short, they make it difficult for squatters to enjoy the comfortable situation they had created.

The goal isn’t confrontation.

The goal is persistence.

What makes the story fascinating is that Shelton didn’t invent a new law.

He simply learned how the existing laws worked and found a way to use them in favor of homeowners instead of against them.

His approach has sparked debate across the country.

Supporters see him as someone helping families recover homes they thought they had lost.

Critics argue that squatter laws exist for important reasons and that every situation is different.

Regardless of where people stand, one thing is hard to deny:

Flash Shelton turned a personal family crisis into a mission that has helped homeowners across America.

Sometimes solving a problem isn’t about fighting harder.

Sometimes it’s about understanding the rules better than the people using them against you.

Father Michael McGivney

Father Michael McGivney

New Haven, Connecticut. 1882.

The knock came early — the kind that only happens when something has already gone terribly wrong.

A woman stood at the door of St. Mary’s Church. Irish. Young. Three children clinging to her skirt, eyes wide with the particular blankness that comes when shock hasn’t yet converted itself into grief. Her husband had been killed in a factory accident. No warning. No savings. Nothing left. In 1882 America, for an Irish Catholic immigrant family, that sentence was the entire story. Here one day. Gone the next. And when the man was gone, everything went with him.

Father Michael McGivney was twenty-nine years old. He stood in the doorway and looked at this woman and her children. Then he looked past them at the neighborhood — the cramped tenement blocks, the men with scarred hands walking to mills that would work them twelve hours and pay them barely enough to keep hunger at a distance.

He had seen this before. He would see it again. Everyone told him it was simply the way things were for people like them.

He went home that night and couldn’t sleep.

Michael McGivney understood poverty from the inside. He had been born the eldest of thirteen children — six of whom died in infancy — to Irish immigrant parents in Waterbury, Connecticut. His father worked in a brass mill, breathing noxious fumes in punishing heat for wages that stretched thin over a crowded house. At thirteen, Michael left school and went to work in the same mill to help the family. At sixteen, he left for seminary, driven by something he couldn’t fully articulate — a calling that felt less like a career choice and more like a command.

He was ordained in 1877 and sent to St. Mary’s Church in New Haven, where he threw himself into the life of a poor immigrant parish with the kind of energy that frightened people who loved him. Morning Mass. Hospital visits. Confession booths past midnight. Street ministry. Funerals — so many funerals.

And after every funeral, the same thing: a widow. Children. Empty hands. No safety net. No help coming.

In New England at the time, several generations of the same family often worked in mills for twelve hours a day, six days a week. There were few social structures to help those who were injured, and little to no support for those who lost a loved one. No insurance company in America would touch Catholic immigrants — they were considered too poor, too foreign, too risky. No government program existed to catch them. The Catholic Church could offer prayers and charity, but charity ran out. And the older priests, the experienced ones who had watched this for decades, offered the young Father McGivney the same weary wisdom: America Magazine

This is just the way it is for people like us.

Michael couldn’t live with that answer.

He began to turn an idea over in his mind — something so simple it was almost embarrassing, the kind of idea that makes you wonder why nobody had tried it before. What if working men pooled small amounts of money together? Not as charity, which carried humiliation. Not as a loan, which carried debt. As a brotherhood. A mutual promise. You fall, we catch your family. I fall, you catch mine.

In early February 1882, largely unnoticed, the young curate assembled eighty Catholic laymen in the basement of St. Mary’s Church. They were factory workers and laborers. Men with calloused hands and worn coats. Men who had buried friends and watched their families dissolve into poverty. Men who knew, bone-deep, what it meant to have nothing. Catholic Courier

Michael stood before them and made a promise that was both modest and enormous.

When one of us falls, the rest of us catch his family.

They needed a name. The society chose Christopher Columbus as its patron — who was Catholic, and at the time considered the discoverer of America — expressing the Knights’ loyalty to both their faith and their country. They were Catholic. They belonged here. They would prove it by caring for each other. Encyclopedia Britannica

They called themselves the Knights of Columbus.

Word traveled through immigrant neighborhoods the way hope always does — faster than fear. Men who had felt invisible in America found something they hadn’t expected to find: each other. Chapters formed in neighboring parishes. Members multiplied. And when men died — as they did, constantly, in factories and on scaffolding and in the dangerous ordinary work of immigrant life — their families received payments. Children stayed in school. Widows kept their homes.

It worked.

In the early days, the Knights’ leaders confronted severe criticism, deep disillusionment, and seriously doubted the value of their efforts. Critics called McGivney reckless. Naïve. They said he was encouraging dependency, that the organization would collapse under its own ambitions. Some questioned whether Irish Catholic immigrants deserved organized protection at all. Catholic Review

McGivney didn’t stop. He traveled to other parishes to establish new chapters. He lobbied the Connecticut state legislature for a formal charter, which was granted in March 1882. He wrote letters, organized meetings, settled disputes between members, and quietly kept the whole fragile structure together through sheer force of belief in what it could become.

And all the while, he was disappearing.

The people closest to him watched it happen — the gradual erosion of a man giving more than he had. He was up before dawn for morning Mass. He was at hospital bedsides in the afternoons. He was in confession booths until midnight. He was writing letters and traveling to chapter meetings on weekends. He ate poorly. He slept when he could. His friends begged him to slow down. His bishop expressed concern. People who loved him saw what he couldn’t seem to see: that he was burning through himself at a rate the body couldn’t sustain.

“There’s no time,” he would say. “Families are suffering right now.”

In 1884, he was assigned as pastor of St. Thomas Church in Thomaston, Connecticut — taking on a second parish simultaneously, driving a horse and carriage between them to serve both communities. His pastoral load would have broken a healthy man. Michael was not a healthy man. He had never been physically robust, and years of relentless work had worn down whatever reserves he had started with.

In January 1890, he contracted pneumonia. He had also been weakened by tuberculosis working through his body. He continued ministering from his bed as long as he could — writing letters, praying for his parishioners, asking about the families he had been helping. Marians of the Immaculate Conception

On August 14, 1890 — two days after his thirty-eighth birthday — Father Michael McGivney died in a rented room in Thomaston, Connecticut.

He was completely spent. Burned all the way down.

He died not knowing whether the thing he had built would last. Not knowing how many people it would reach. Not knowing whether the exhausted years and the missed meals and the sleepless nights had added up to something that would survive him, or whether it would quietly fold without the man who had willed it into existence.

He had given everything he had to something he would never see completed.

And then history took over.

No one, least of all Father McGivney, suspected that over a century later the Knights of Columbus would grow to be an international body of around 2 million Catholic men and a powerful force for good. Today the organization spans the United States, Canada, Mexico, the Philippines, the Caribbean, Central America, Poland, Ukraine, and Lithuania. They have given billions of dollars to charitable causes. They have built hospitals. They have funded disaster relief operations across multiple continents. They have supported refugees, fed the hungry, stood beside the sick and the dying in dozens of languages in dozens of countries. Every year, at the local and international level, the Knights give away millions of dollars to people who need it — quietly, without announcement, the way the man who started it all once helped families in the basements of Connecticut churches. Catholic Courier

In 2020, Pope Francis declared him Blessed Michael McGivney — one step from official sainthood — calling his “zeal for the proclamation of the Gospel and generous concern for the needs of his brothers and sisters” a witness of Christian solidarity that had made him an outstanding example of fraternal assistance. Fathermcgivney

He never heard that. He never saw any of it.

He died in a rented room, thirty-eight years old, believing he had made a small dent in one corner of a suffering world — and not entirely sure even that would last.

He had no idea.

There is something in this story that reaches beyond religion, beyond history, beyond the specifics of Irish immigrants in nineteenth-century Connecticut. It touches something true about how the most important things in the world actually get built.

Not by people who could see the finished cathedral. By people who placed one stone, trusted it mattered, and went back the next day to place another.

Most of us will never know the full size of what we’re building. We raise children whose children will do things we cannot imagine. We plant kindness in people who carry it somewhere we’ll never see. We build things that outlive us by generations, and we die without ever reading the final chapter.

Michael McGivney died on a Tuesday in August, certain he hadn’t done enough.

Two million people around the world continue the work he started.

If you are showing up, day after day, for something that feels too small, too slow, too thankless — if you are planting in ground you may never harvest, building something you may never see finished —

You are in very good company.

And somewhere, decades from now, someone will be alive because of what you did today.

Even if you never know their name.