Jessica continues to impress me as a formidable scientist and highly intelligent thinker. Her substacks are the only ones I still read. Recently, I read her following contribution:
In light of DNA discovered in commercial vials as per the precautionary principle… (substack.com)
I completely agree with Jessica. These bastards cannot get away with simply doing some proper cleaning-up and QC on the end product. As she states correctly: “The problems associated with the modified mRNA COVID-19 injectable products is not only a problem of DNA contamination. This is yet an additional problem associated with the modified mRNA products”. Of course, there is the toxicity of the LNPs too, but there is another huge, immunological concern. All the immunological and molecular epidemiology data collected from populations that are vaccinated with mRNA-based C-19 vaccines clearly indicate that these vaccines lead to immune refocusing. This is because mRNA-based C-19 vaccines generate low-affinity antibodies against spike (S) protein that is expressed on the surface of transfected host cells* (this is something which clearly does not occur during natural infection of host cells with SARS-CoV-2 as I extensively explain in my book: “The inescapable immune escape pandemic”). Induction of low-affinity Abs towards a foreign Ag that is expressed on the surface of the body’s own cells (outside of antigen-presenting molecules!) inevitably triggers immune pathology (e.g., Ab-dependent and complement-dependent cell cytotoxicity; ADCC and CDCC). Because these low affinity Abs mask the immunodominant domains on S protein, they force the immune system to concentrate on other – more conserved – antigenic domains. However, as the latter are immune subdominant (i.e., have lower intrinsic immunogenicity), the elicited (cross-neutralizing) Abs rapidly reach suboptimal concentrations. Large-scale presence of suboptimal concentrations of neutralizing Abs generates population-level immune selection pressure, which drives immune escape. In other words, even the ‘cleanest’ mRNA-based C-19 vaccines will always promote immune pathology and drive disastrous viral immune escape. As a seasoned vaccinologist, I am therefore of the opinion that no mRNA-based injectable product should ever be used for immunization purposes. After all, the purpose of vaccines is to generate immune protection and not to induce immune pathology or enhance disease! (FIRST, DO NO HARM!).