A primer on Chronic Fatigue Syndrome

Chronic Fatigue Syndrome

Written By: Courtney Craig

With over a million Americans diagnosed Chronic Fatigue Syndrome it is important to identify natural solutions to alleviate suffering….

Chronic Fatigue Syndrome, or CFS, is a serious illness with a terrible name.

CFS has been described as the flu that never goes away. Throughout the rest of the world, CFS is more accurately named Myalgic Encephalomyelitis, or ME. Many patients and clinicians have now adopted the combined term ME/CFS, with the belief that the name Chronic Fatigue Syndrome has the potential to cause harm to patients. Labeled with this diagnosis, patients are frequently dismissed from doctor’s offices under a psychiatric cloud, or erroneously told to exercise back to health. However, the defining characteristic of ME/CFS that differentiates it from other conditions, depression included, is post-exertional malaise. A simple bout of mental or physical activity can trigger flu-like symptoms in patients with lasting effects.

Imagine a trip to the mailbox being enough to confine you to bed for the rest of the day … or longer.

Despite growing numbers stricken -1 million Americans – research funding for the disease has remained paltry for nearly 3 decades. Many in mainstream medicine still do not accept the illness as organic, and all too often malign it with psychosomatic or conversion disorders. Worse still, many patients are not accepted by family or loved ones.

Is it any wonder then that a leading cause of death in this group of patients is suicide?

Fatigue alone does not even begin to describe what a patient with ME/CFS experiences on a daily basis. Lack of understanding leads to onlookers assuming laziness, de-conditioning, or simply over-work. Yet, the fatigue felt has been compared to the level of fatigue experienced by end-stage cancer or HIV/AIDS patients. Severely debilitating symptoms afflict those with the illness: cognitive problems, pain, irritable bowel, autonomic dysfunction, sleep disturbance … the list goes on. The larger impact of this illness is that disability due to ME/CFS is estimated to cost $9.1 billion in lost productivity every year in the US.

Research has not been able to pinpoint the exact cause or trigger for ME/CFS. A diagnostic marker remains elusive. However, many unique physiological signatures have been determined. As an example, abnormal cytokine and immune cells are hallmark findings. Certain cytokine patterns are thought to drive sickness behaviors and contribute to hypersensitivity to pain. Most patients also have limited natural killer (NK) cell number and function. This finding may be associated with increased rates of certain cancers in patients as well as harboring of opportunistic infections. Finally, patients have limited cardiopulmonary capacity and blood flow irregularities. These findings may explain the intolerance to exercise and depressive symptoms due to poor cerebral profusion.

Is It Autoimmune?
While not classically defined as an autoimmune disease, there are striking similarities between ME/CFS and conditions such as Multiple Sclerosis. In fact, as many as 60% of patients have a comorbid autoimmune diagnosis. The chronic or recurring viral infections common in many patients can induce autoimmunity by molecular mimicry and bystander activation. Similar to autoimmune conditions, viruses can flip a switch on the immune system leading to loss of “self” recognition. Others note the onset of illness following a vaccination, suggesting an autoimmune (auto-inflammatory) syndrome induced by adjuvants.

Is It In The Cells?
Many ME/CFS patients mind their mitochondria — the vitally important energy supply house of the cell. Numerous studies have demonstrated mitochondrial insufficiency in patients which is likely due to a vicious cycle of oxidative stress. Inflammatory cytokines and other immune cells propagate reactive oxygen species that damage cellular membranes, myelin, and mitochondria. As a consequence, studies have noted severely depleted CoQ10 in patients suggesting mitochondrial dysfunction. This finding also supports the epidemiological evidence that ME/CFS patients are more prone to develop cardiovascular diseases, since CoQ10 is vital for heart health. Some reports have found congestive heart failure can occur 25 years earlier in ME/CFS patients than in the general population.

Is It In The Brain?
Advanced imaging studies in ME/CFS found widespread neuroinflammation in several key brain regions including the cingulate cortex, hippocampus, amygdala, thalamus, midbrain, and pons. Inflammation in these areas was 45%-199% times higher in ME/CFS patients than in healthy controls. Interestingly, the degree of neuroinflammation directly correlated with symptom severity. Larger studies are underway to determine which inflammatory marker is driving the vicious cycle of inflammation. At the moment, all eyes are on leptin. Leptin measured daily in a small cohort of patients was found to correlate with the degree of neuroinflammation. This inflammatory molecule released from fat tissue, can activate microglia in the brain which promotes neuroinflammation.

Still other studies have shown that ME/CFS patients have reduced white matter and abnormalities in gray matter, potentially offering additional clues to explain the cognitive difficulties and brain fog patients endure. Lastly, a recent study showed reduced Brain-Derived Neurotrophic Factor (BDNF) in ME/CFS patients that was far greater than in MS patients suggesting an obstacle in neurogenesis and plasticity.

Is It In The Gut?
Acclaimed virus hunter Dr. Ian Lipkin has launched a crowd-funded project to study the microbiome in ME/CFS. Putting aside the idea of viral etiology, Lipkin and his team at Columbia hope to find a unique dysbiotic signature in these patients (http://www.microbediscovery.org/). An exciting 2013 study in Belgian and Norwegian patients, found altered intestinal microbiota that may be linked to the pathogenesis of the illness.

Other researchers are also thinking about the role of the gut in this illness. A seminal paper from 2014 proposed that the latent viral infections harbored by ME/CFS patients can have major effects on cognitive function due to translocation via the vagus nerve. Could it be that viruses or bacteria harbored in the digestive tract of ME/CFS patients can exert effects on the brain using this cranial nerve as passageway?

How To Intervene
Just because ME/CFS remains a medical mystery should not suggest patients have no options for symptom relief. Without a FDA-approved medication for the illness, many patients look to integrative and functional medicine doctors to manage their most severe symptoms. With the information currently available, evidenced-based interventions can be applied.

It Starts With Food
Undoing the cycle of inflammation can be best addressed by starting with an anti-inflammatory diet. This may provide modest relief of pain or fatigue in many patients. A nutrient-dense diet also provides abundant cofactors to promote energy production at the cellular level. Gut healing dietary strategies can also be utilized to ensure intestinal integrity and immune function. Many patients eliminate known gut irritants such as gluten, dairy, alcohol, and refined sugars.

Smart Supplementation
Seldom is diet alone sufficient to make a substantial impact on severe ME/CFS. Most patients rely on a suitcase of supplements with the hope of finding the right combination. While research is slim in this arena, evidence grows for the need for mitochondrial nutrients as well as basic vitamin and mineral cofactors. One study showed significant improvement with just 2 months of supplementation with a multivitamin/multimineral.

Immune boosting nutrients are commonly utilized to support a healthy immune response, prevent viral reactivation, and improve NK cell function. These include such nutrients as transfer factors, medicinal mushrooms, and curcumin. Anti-inflammatory nutrients are also indicated including omega 3 oils, vitamin D, and antioxidants like resveratrol and EGCG.

Mind and Body
Few can relate to the hopelessness that comes from living with a chronic illness for decades. Patients wrestle with the bleak reality that they may never completely recover. Finding hope through healthy attitudes and habits is of vital importance for these patients. Learning to say no, allowing adequate time for rest, and carefully pacing throughout the day are the norm for a patient with ME/CFS. Cultivating acceptance and practicing mindfulness provide other tools patients can use to cope. Mindfulness meditation is now accepted as a practice that can impact brain health and reduce the physiological stress response. Mind-body practices help many patients achieve better sleep and promote a deeper level of healing.

Editor’s note: this excellent review did not identify the role of retroviruses in CFS/ME syndrome. For a deeper appreciate for their role in the pathogenesis of CFS/ME read the book Plague, or listen to Greenmedinfo.com founder Sayer Ji’s interview of its co-author, Judy Mikovits, PhD, on Fearless Parent Radio.

© January 12th 2015 GreenMedInfo LLC. This work is reproduced and distributed with the permission of GreenMedInfo LLC. Want to learn more from GreenMedInfo? Sign up for the newsletter here www.greenmedinfo.com/greenmed/newsletter.

https://nexusnewsfeed.com/article/health-healing/a-primer-on-chronic-fatigue-syndrome/

Memory Retention Tips – 5 Don’t and 5 Dos.

MSG is a toxic food additive that many report causes headaches.

Aspartame/NutriSweet/Equal accounts for 75% of the adverse reactions reported to the FDA.

Sucralose/Splenda is an artificial sweetener that is also linked to mental function loss.

Avoid foods that contain the enzyme Diacetyl which is an ingredient added to many processed foods to add flavour.

Microwave popcorn has been linked to Alzheimer’s. The chemical added to make it taste buttery crosses the blood/brain barrier to cause amyloid proteins, the tell tale marker of Alzheimer’s.

Bacopa
Ginkgo Biloba
Acetylcholine
Huperzine from Club Moss
Phosphatidylserine

Sustaining Your Health

“A diet rich in whole foods and low in processed ingredients is fundamental to sustaining optimal health and preventing chronic disease.” – Drewnowski & Specter, 2004, American Journal of Clinical Nutrition, 79(1), 6-16

At 70, if you can still do these six things, you’re winning at life.

Purpose Is Not A Luxury

Reaching 70 is a milestone, but true success lies in maintaining key abilities that define a fulfilling life. If you can still think critically, stay physically active, nurture relationships, keep learning, contribute meaningfully, and find joy in everyday moments, you’re truly winning. Inspired by Jordan Peterson’s wisdom, this motivational speech emphasizes resilience, purpose, and self-improvement. Life isn’t just about longevity but about staying engaged, strong, and mentally sharp. Aging well means embracing challenges, adapting to change, and continuing to grow. If you can do these six things, you haven’t just lived long—you’ve lived well. Keep pushing forward!

https://www.youtube.com/watch?v=huZlkgLyPbY

Earth Air Tunnel

Earth Air Tunnel

an Earth Air Tunnel (EAT) system, a passive cooling and ventilation technique that utilizes underground pipes to regulate indoor temperatures. Hot air at 35°C is drawn into a wind tower or wind catcher, where it passes through an underground pipe system at a minimum depth of 2 meters. As the air moves through the tunnel, the earth’s stable temperature cools it to 25°C, providing natural air conditioning. The cooled air is then distributed into the house, creating a comfortable indoor climate. Warm air inside the home is expelled through vents, maintaining continuous airflow and preventing heat buildup. This system is energy-efficient, reducing reliance on mechanical cooling methods like air conditioning. It is particularly effective in hot climates, offering sustainable temperature regulation with minimal energy consumption.

A tale of two brains: how your second brain is key to understanding many chronic illnesses

Inflammed Gut

While the author shares some valid data and makes good recommendations, I believe he misunderstands the concept of intuition. (Intuitive: using or based on what one feels to be true even without conscious reasoning; instinctive.)

A being is intuitive, a piece of matter, such as a body part, is not. There are biochemical signals that produce a variety of reactions in the gut. No little man down there “feeling” or being intuitive.

https://nexusnewsfeed.com/article/food-cooking/a-tale-of-two-brains-how-your-second-brain-is-key-to-understanding-many-chronic-illnesses/

Cellulitis

Cellulitis is usually caused by a bacterial infection. Group A streptococcus and staphylococcus aureus (‘staph’) are the most common bacteria involved. These bacteria normally live on your skin without causing any harm, but if your skin is broken they can infect your tissues and cause cellulitis. The infection usually happens when bacteria enter your skin through an ulcer, cut, scratch or insect bite. It can also happen if you already have a skin problem like eczema, psoriasis, scabies or acne, or after surgery. However, it may happen without any visible damage to your skin.

A common cause of cellulitis is scratching your skin with dirty fingernails that carry bacteria.

You’re more likely to get cellulitis if you have a skin condition that makes you itchy and are more likely to scratch. You’re also more likely to get cellulitis if you:
smoke
live with obesity
have diabetes
have poor circulation or a weakened immune system
have swelling in an arm or leg, such as with lymphoedema

It often affects your lower leg but can occur anywhere on your body.

You may have cellulitis if you have an area of skin that is warm, red, tender and very painful.

If your infection is severe, you may also have symptoms like fever and nausea.

If you think you or someone in your care has cellulitis, it’s important to get medical attention as soon as possible.

How is cellulitis treated?
Cellulitis is usually treated with:
antibiotics
rest
elevating or raising the affected part of your body, if possible

(A client told me that the most effective antibiotic by far is the original penicillin, one not easily prescribed by doctors.)

While cellulitis is not generally contagious, it’s important to always wash your hands before and after touching the infected area.

https://www.healthdirect.gov.au/cellulitis

Study Links Fiber Consumption to Epigenetic Changes with Anticancer Effects

Fiber

  • Fiber byproducts — short-chain fatty acids — physically attach to DNA regions, influencing how genes are turned on or off through epigenetic regulation
  • A comprehensive review of 11 meta-analyses found that higher fiber consumption correlates with reduced risk of several cancers, including gastric, esophageal, ovarian and endometrial tumors
  • Fiber helps regulate hormone pathways and curbs inflammation, with studies showing it may reduce estrogen reabsorption, lowering the risk of hormone-related cancers like breast cancer
  • Research indicates modern diets often lack adequate fiber, leading to chronic metabolic strain and disrupted digestive processes, making fiber optimization an important public health strategy
  • People with compromised gut health should introduce fiber gradually, starting with easily digestible carbohydrates like white rice and fruit juices before progressing to more fibrous foods. In severe cases, start with dextrose water

https://articles.mercola.com/sites/articles/archive/2025/02/27/fiber-consumption-and-epigenetic-changes-anticancer-effects.aspx