Have we unleashed a plague of IgG4-related disease on a subpopulation of humans?
Jeff Childers writes:
The study we reviewed on Monday about the IgG4 antibody shift is spreading widely. In just two days, most of the usual covid commenters have written about the story, and even rabidly pro-jab folks have noticed:
Dr. Eric Topol is an influential, full-throated, unapologetic vaccine advocate. For him to observe that “the clinical significance is not known” is shocking. I would’ve expected him to include some kind of reassuring or optimistic comment downplaying the study, or at least ignore it.
The main point seems to be sinking in:
There are a couple takeaways. First, “fully vaccinated” (two dose) folks may not yet be in the danger zone. The researchers didn’t find IgG4 antibody replacement began in earnest until after the 3rd booster, and especially after the 3rd booster and reinfection.
The study has lots of leg. Things are making more and more sense.
The results suggest the repeated shots — never before tried at scale, I might add — are overwhelming the body’s immune system. In order to prevent “immune overload” (a deadly cascade of autoimmune problems), the body says, well boys, we’ll just have to tolerate this for a while, stop shooting and buckle up.
Next, tolerance would explain both why boosted people are getting reinfected so often and also why their infections may appear mild. Their infections appear mild because the body is suppressing its systemic immune response: no fever, no headache, no congestion, no coughing. But their infection is raging away invisibly.
Finally, and maybe most important, people may want to strongly consider STOPPING BOOSTING until this thing gets sorted out. It’s almost certainly the continued boosting that is causing tolerance. I know this sounds shocking, but repeat injections of a toxic genetic antigen over a short period of time might not have been the very best idea they came up with during the pandemic.
https://jessicar.substack.com/p/the-immunological-mechanism-of-action