Fiber For Brain Health

Fiber For Brain Health

Almost nobody eats the recommended amount

In recent years, carbs (short for carbohydrates) have been heavily criticized for their role in diseases, including brain issues. There’s a basis for this, as our modern diets are loaded with low-quality “empty carbs” like added sugars and refined baked goods, both of which may create issues in the brain when consumed regularly by way of metabolic and immune effects. Yet emerging research suggests that one of the most powerful nutrients for overall and brain health could be a carb, and almost nobody is eating the recommended amount. In this article, we’re breaking down the science on dietary fiber, and why it may still be one of the best-kept secrets for longevity, overall wellness and especially brain health and cover considerations around low-carb diets.

Dietary fiber is a carbohydrate (or carb) that’s indigestible to humans. This means we don’t break it down into sugar molecules, and that it passes through the stomach and small intestine to reach the large intestine intact. The data on fiber intake in the United States is sobering. Health guidelines recommend approximately 14 grams of fiber per 1,000 calories consumed — roughly 25 grams per day for women and 38 grams for men. Yet research consistently shows that the average American is consuming only about 10 to 15 grams per day, less than half the recommendation. More striking still, research suggests that only 5% of Americans are eating the recommended levels of fiber. This isn’t a US issue alone. Less than 10% of UK adults hit the recommended mark, and lower than optional levels of intake are seen from Mexico to European countries.

Fiber’s link to health

Decades of research suggests that a higher fiber diet may help to prevent cardiovascular issues, improve blood sugar, increase lifespan and decrease risk for a host of other issues, including brain health conditions. These types of data were most recently confirmed in a massive review of over 17 million people across 33 separate meta analyses.

As it relates specifically to the brain, an observational study on nearly 4000 Japanese adults found that those eating more fiber had a roughly 20% lower risk for developing disabling dementia over the observational period, with the biggest benefits seen with soluble fiber. In a 2025 randomized, placebo-controlled trial looking at multiple interventions, researchers found that people who took fiber had changes in the gut microbiome and improved cognition versus the placebo. Finally, in another 2025 study, scientists found a link to cognitive improvements in those eating more fiber with a peak benefit between 22 and 30 daily grams of consumption. While there’s lots still to learn, a key mechanism seems to involve benefits to the gut-brain axis that come from eating more fiber.

Why are people eating so little fiber? Modern food is a big reason. As we moved towards industrialized food products, especially refined grain products, we kept the carbs but lost the fiber. Data show that in general, the more ultra-processed food we consume, the less fiber we consume. Contrast this with our ancesters diets which are believed to have added up to 100 grams of fiber a day to our diets!

What are the different forms of fiber?
Two types of fiber are commonly described, although the reality is that there’s a whole lot of nuance, even there. Insoluble fiber, found in whole grains, nuts and seeds, fruits (especially the skins) and leafy greens veggies doesn’t dissolve in water, and it helps aid in GI transit. Soluble fiber turns to a gel when we consume it and high in nuts, beans, fruits and chia seeds. It’s believed to help us feel full, in part by slowing digestion. As you can see, there’s considerable overlap in food sources, and a key consideration across the board here is that these foods are plant-based and mostly minimally processed whole foods.

Beyond these basics, some fibers are called “fermentable,” which means then can be digested by the microbes living in your gut. Many studies now additionally call attention to specific “functional” fibers like beta-glucans (which come from oats, barley, mushrooms and even algae) and resistant starch, which is high in unripe bananas and cooled rice. While there’s lots of interesting studies looking at various forms of fiber to consume, many expert sources like Harvard and the Mayo Clinic echo the same idea: focus on eating more fiber rich foods rather than hyper-focusing on nailing the specific forms of fiber.

Adding too much fiber into our diets, and especially if we do so quickly, is linked to increased bloating and other GI discomfort. This may be even more the case when we up our intake of fermentable fiber. Experts recommend increasing fiber intake by a few grams a day with adequate water, along with monitoring for tolerance. Additionally, those with preexisting GI issues or those undergoing or recently undergoing GI procedures may have more risk from increasing fiber intake.

What about all-meat or low FODMAP diets?
Fiber isn’t an “essential nutrient” in that don’t absolutely need it for survival, and there’s no defined “deficiency” state. That’s led many to challenge the idea that we need it at all.

For some individuals, particularly those with significant food sensitivities, elimination diets like carnivore can provide genuine short-term relief. Removing certain plant foods can meaningfully reduce bloating and GI distress for certain people with IBS — and that relief is real. It’s also true that our understanding of the microbiome is still evolving, and not every aspect of it is settled science.

With this said, the data are increasingly clear that eating more fiber for most people is a good bet for better overall health. This is where it’s helpful to speak to a qualified nutrition and health professional (like your doctor or dietician) to better understand your body and needs.

Some general ideas on how to incorporate more fiber into your day:

Finish reading: https://www.austinperlmutter.com/post/the-missing-carb-that-could-be-protecting-your-brain
1. Start your day with a fiber
Most people miss a huge opportunity at breakfast. Build in a higher fiber option with chia pudding, nuts, seeds, some greens or beans with your eggs, fruits or a fiber-rich smoothie

2. Add extra fiber on your favorite meals
Layer fiber onto your food with some ground flax seed on your yogurt, beans or lentils on your salad, or some extra veggies with your dinner.

3. Opt for plants with every meal
Distributing a bit of fiber into every meal can help you reach your fiber goals without being too concerned about any one opportunity. Think black beans with your morning eggs, seeded bread with your sandwich, and almonds with your dark chocolate for dessert.

Below is a list of some high fiber foods and the amount of fiber per serving

Vegetables
Broccoli (cooked) — 1 cup ~5 g
Brussels sprouts (cooked) — 1 cup ~6 g
Carrots (raw) — 1 medium ~2 g
Sweet potato (with skin) — 1 medium ~4 g
Spinach (cooked) — 1 cup ~4 g

Fruits
Apple (with skin) — 1 medium ~4 g
Banana — 1 medium ~3 g
Raspberries — 1 cup ~8 g
Pear (with skin) — 1 medium ~5–6 g
Avocado — ½ fruit ~5 g

Whole Grains
Oats (cooked) — 1 cup ~4 g
Quinoa (cooked) — 1 cup ~5 g
Brown rice (cooked) — 1 cup ~3.5 g
Whole wheat bread — 1 slice ~2–3 g
Barley (cooked) — 1 cup ~6 g

Legumes
Lentils (cooked) — 1 cup ~15–16 g
Black beans (cooked) — 1 cup ~15 g
Chickpeas (cooked) — 1 cup ~12–13 g
Kidney beans (cooked) — 1 cup ~13 g
Split peas (cooked) — 1 cup ~16 g

Nuts & Seeds
Chia seeds — 2 tbsp ~10 g
Flaxseeds (ground) — 2 tbsp ~4 g
Almonds — 1 oz (~23 nuts) ~3.5 g
Pumpkin seeds — 1 oz ~1–2 g
Hemp seeds — 2 tbsp ~1–2 g

https://www.austinperlmutter.com/post/the-missing-carb-that-could-be-protecting-your-brain

Best Diets For Dementia Prevention: Results From Over 121,000 People

Diets For Brain Health

Every week, there’s a new conversation about a superfood, supplement or toxic ingredient for brain health. And as of right now, the significance of almost every one of these topics pales in contrast with the effect of overall dietary patterns. Now a landmark study from the UK Biobank further solidifies this point, tracking over 121,000 people across an average of nearly eleven years. These findings carry real implications for every one of us who cares about keeping our minds sharp as we age.

The research was published in Diabetes, Obesity and Metabolism in 2025 and examined how closely following four different dietary patterns affected the risk of developing all-cause dementia, Alzheimer’s disease, and vascular dementia in 121,521 participants (average age about 56, roughly 50/50 men and women). The four diets evaluated were the Mediterranean Diet Score (MDS), the MIND (Mediterranean-DASH Intervention for Neurodegenerative Delay) diet, the Recommended Food Score (RFS), and the Healthy Diet Indicator (HDI). Participants were grouped into quartiles based on how closely their reported diets followed each pattern and were then tracked for about 11 years to look for whether they developed dementia. People with preexisting dementia were excluded from the trial. The research models accounted for smoking, physical activity levels, social interactions, BMI, preexisting medical issue and even air pollution exposure.

The Mediterranean Diet: overall winner for lower risk for dementia

The findings in this study confirm something a variety of other articles have concluded: the value of the Mediterranean Diet. In this study, people in the highest adherence group showed a 47% lower risk of all-cause dementia compared to those with the lowest adherence. For Alzheimer’s disease specifically, the risk reduction was 45%. For vascular dementia the risk was as astonishing 54% lower hazard ratio.

Anchored in plant nutrients, fiber and healthy fat-rich foods like olive oil, fatty fish, abundant vegetables and legumes, whole grains, nuts, and moderate wine, this pattern delivers a concentrated payload of anti-inflammatory polyphenols, omega-3 fatty acids, and antioxidants that may directly support neuronal integrity and cerebrovascular health, in part through beneficial effects on the gut, which communicates directly with the brain via the gut-brain axis. Chronic, low-grade inflammation is one of the most well-established drivers of neurodegeneration, and this dietary pattern attacks it from multiple angles simultaneously. That’s the power of a food pattern versus a single nutrient.

The MIND Diet: Another Top Contender

The MIND diet, which was specifically engineered for dementia prevention, performed well. A hybrid of the Mediterranean and DASH diets, it emphasizes leafy greens, berries, nuts, whole grains, fish, poultry, and olive oil, while limiting red meat, butter, cheese, pastries, and fried food. Those eating the closest to a MIND type diet experienced a 39% lower all cause-dementia risk. High MIND adherence was also associated with a lower risk of all-cause dementia, Alzheimer’s and vascular dementia.

What This Means

The practical message from this research is both encouraging and clarifying. Sticking to relatively non-restrictive dietary patterns are strongly linked to brain protection. Consistent adherence to a whole-foods-forward, anti-inflammatory eating strategy — one that prioritizes vegetables, fruit, legumes, whole grains, healthy fats, and quality protein, while minimizing processed foods and refined sugars is a generally good bet for long-term brain protection. Whether you call that Mediterranean, MIND, or simply “eating well,” the biology underlying the benefit is largely the same.

Diet is one pillar of brain health, and a critical one — but it works best in concert with sleep, movement, stress management, and social connection. The brain is an organ that reflects the totality of how we live.

Finally, a word of appropriate scientific context: this is an observational study. The researchers took important steps to minimize reverse causation (aka, that people chose dietary patterns because they had existing brain issues) but we cannot draw causal conclusions. What we can say, with growing confidence, is that the association between high-quality dietary patterns and reduced dementia risk is robust, biologically plausible, and worth taking seriously.

Your fork, it turns out, may be one of the most powerful brain health tools you own.

https://www.austinperlmutter.com/post/the-top-diets-for-dementia-prevention-according-to-a-major-new-study

Food Prep Tips

Because one of the biggest nutrition mistakes I see has nothing to do with what people are eating. It’s how they’re preparing it.

The right food, prepared the wrong way, can lose the very compounds that make it worth eating in the first place.

Here are six simple fixes that change everything.

  1. BROCCOLI: Chop it. Then walk away.

When you cut broccoli, it triggers the formation of sulforaphane, one of the most studied anti-inflammatory compounds in food science.

Research shows it can block cancer cell growth, reduce oxidative stress, and even cross the blood-brain barrier to protect your brain.

But sulforaphane needs about 40 minutes to fully form after the cell walls are broken.

Chop your broccoli and throw it straight into the pan? The heat destroys the enzyme before the sulforaphane ever activates.

The fix? Chop first. Prep everything else. Cook it last.

  1. GARLIC: Crush it. Wait 10 minutes.

Garlic’s most potent compound, allicin, only forms when the cell walls are crushed and the enzyme alliinase is exposed to air.

Cook it immediately and the heat destroys the enzyme before allicin can form.

But crush or chop it and wait just 10 minutes? Those 10 minutes are the difference between flavouring and genuine medicine.

Allicin is a broad-spectrum antimicrobial that fights harmful bacteria, supports liver detox, and reduces key inflammatory markers.

  1. TOMATOES: Cook them. Add fat.

Unlike most vegetables, tomatoes become more nutritious when cooked.

Heat breaks down the cell walls and significantly increases the bioavailability of lycopene, a powerful antioxidant linked to heart and brain health.

But lycopene is fat-soluble. Without a drizzle of olive oil or a few slices of avocado, your body can barely absorb it.

  1. TURMERIC: Always add black pepper.

Your body absorbs almost none of the curcumin in turmeric on its own.

But adding black pepper increases absorption by up to 2,000%.

The piperine in black pepper blocks your liver from breaking curcumin down too quickly. A generous pinch is all it takes. Adding a healthy fat like coconut milk or olive oil boosts it even further.

This is why traditional golden milk recipes have always included pepper and fat. They figured it out long before the clinical trials caught up.

  1. MUSHROOMS: Put them in the sun.

Mushrooms are the only non-animal food that can produce vitamin D.

Place them gill-side up in direct sunlight for 15 to 30 minutes before cooking and they convert ergosterol into vitamin D2, just like your skin does.

Any variety works. Even store-bought white buttons.

  1. RICE, PASTA, POTATOES & OATS: Cook them and then cool them.

When starchy foods cool down after cooking, some of the digestible starch converts into resistant starch, a prebiotic fiber that your gut bacteria ferment into butyrate and other short-chain fatty acids.

The best part? Resistant starch largely survives gentle reheating.

So cooking a batch of rice or potatoes, refrigerating them, and reheating the next day gives you the same meal with bonus prebiotic benefits.

Your gut bacteria get fed without you changing a single ingredient.

For oats specifically, soaking them overnight also allows the beta-glucan fiber to fully hydrate, maximising its cholesterol-lowering and prebiotic effects.

None of these take more than a minute of extra effort. Most take zero.

They’re just tiny shifts in timing and preparation that unlock compounds your body and your gut bacteria are designed to use.

Your food is already powerful. It just needs you to prepare it in a way that lets it do its job.

Yours for better health, naturally

Sarah Otto
Nutritionist (Master of Human Nutrition)

Five Fitness Tips

Five Fitness Tips

Robert Verkerk PhD writes: “We need to be able to develop real powerful mitochondrial efficiency. We have enough energy in the system. And we need to recover from stress, from physical activity, from emotional stress, any of the stresses that are thrown at us. Those are the 3 keys. And so I’m now going to take you into some myths that I’ve been hearing about that I think are commonplace.”

https://anhinternational.org/news/5-fitness-myths-that-are-undermining-your-endurance-and-long-term-health/#elementor-toc__heading-anchor-0

Weight Loss – Black Box Warning

Weight Loss - Black Box Warning

Look around. Everyone’s talking about the same thing.

The triangle-shaped pen. The weekly injection. The pounds melting off like magic.

Ozempic. Wegovy. Rybelsus. Mounjaro. Whatever name they slap on it, the promise is the same: eat less, weigh less, fast. No willpower required. No sweating in a gym. Just a little poke in the belly and suddenly food loses its grip on you.

Sound too good to be true? That’s because it is.

https://thetruthaboutcancerofficial.substack.com/p/ozempic-lies-vs-the-healthy-truth

91% of Flu Vaccine Recipients Shed Chimeric Lab-Made Vaccine Virus

Nasal Swab

A newly published, U.S. government-funded, peer-reviewed study has confirmed that a live attenuated influenza vaccine caused detectable post-vaccination viral shedding in more than 91% of adult recipients, raising major questions about whether vaccinated individuals function as carriers and spreaders of vaccine-derived influenza pathogens after immunization.

The findings, published Thursday in the journal Clinical Infectious Diseases, claim that the purported virus inside the vaccine actively replicated inside recipients after administration and was subsequently shed from the nose in the overwhelming majority of participants.

Researchers from George Washington University evaluated 283 healthy adults between the ages of 18 and 49 who received the intranasal live attenuated influenza vaccine (LAIV), FluMist, during the 2023–2024 and 2024–2025 flu seasons.

Study Only Looked for 7 Days

Importantly, the researchers stopped monitoring participants after approximately seven days.

That means the study cannot determine:

  • how many participants continued shedding beyond day 7,
  • how long shedding ultimately persisted,
  • or when the slow-clearance group fully stopped shedding vaccine-derived influenza material.

https://open.substack.com/pub/jonfleetwood/p/91-of-flu-vaccine-recipients-shed

Vaccines Cause Disproportionately More Harm Than Good

US Senate Hearing On Vaccines

In a major study of the different health outcomes between the vaccinated and unvaccinated covering 62,000 children, the following results stand out:

Health Condition Unvaccinated Vaccinated
Chronic Health Issue 17% 57%
Asthma Baseline 4.29x
Atopic Disease Baseline 3.03x
Autoimmune Disease Baseline 5.69x
Neurodevelopmental Disorders Baseline 5.53x
Mental Delay Baseline 3.28x
Speech Disorder Baseline 4.47x
ADHD none 260 cases

“There was also other conditions for which there were numerous cases in the vaccinated group but zero in the unvaccinated group hence the rate cannot be calculated including brain dysfunction, ADHD, learning disabilities, intellectual disabilities and ticks.

“17% of unvaccinated have a chronic health issue compared to 57% of vaccinated.”

This study was concluded and never submitted for publication as the author did not want to lose his job or upset doctors. This is a classic example of how profit motive, funding influence and coercion have suppressed the truth and corrupted the medical profession by installing an almost cult-like vaccine ideology that cannot be questioned without considerable backlash and why the healthiest thing you can do is to, as much as possible, build a health support system outside the allopathic medical disease system/racket.

Good nutrition and an exercise routine appropriate to your current state of fitness are two of the 28 levers I have identified that you can push to move your spirit/mind/body combination in the direction of optimal health. To learn more about them, get a hold of my book, How To Live The Healthiest Life.

To view the video: https://x.com/thehealthb0t/status/2052643250847326455?s=20

Fran Drescher

Fran Drescher

In 1998, Fran Drescher was untouchable.

She had created, produced, and starred in The Nanny — one of the most-watched sitcoms on the planet. Her character, Fran Fine, the big-hearted, loud, impossibly stylish woman from Queens, had made her a household name in over 60 countries. By the show’s final season, she was among the highest-paid actresses on American television.

From the outside, her life looked perfect.

Inside, something was quietly falling apart.

It started with symptoms that felt impossible to ignore — cramping, irregular bleeding, a persistent pelvic pain that didn’t respond to anything. She made an appointment with her doctor. Then another. Then another.

Each one ran tests. Each one delivered the same calm, confident verdict:

Perimenopause. Perfectly normal for your age.

She tried hormone replacement therapy, as recommended. It made things worse. The bleeding intensified. The pain didn’t ease.

“Something is really wrong,” she told doctor number six.

“You’re too young for anything serious,” he replied.

“You’re too thin to fit the cancer profile,” said another.

One doctor — and this part is not a joke — told her she was probably eating too much spinach.

For two years, Fran saw eight different doctors. None of them ordered the one test that could have answered everything: a simple endometrial biopsy.

She wasn’t a hypochondriac. She wasn’t overreacting. She was a woman describing real symptoms to credentialed professionals, and every single one of them sent her home.

Then she found doctor number eight.

This physician looked at two years of medical history — the dismissed symptoms, the failed treatments, the worsening pattern — and said four words that changed everything:

“Let’s do a biopsy.”

Three days later, the phone rang.

Uterine cancer. Stage I. Growing inside her for years while doctor after doctor told her she was fine.

She was 42 years old.

The surgery was successful. The cancer was removed. She was going to live.

But Fran couldn’t simply move on.

In 2002, she published a memoir — Cancer Schmancer — about navigating a medical system that had nearly cost her everything. She expected to share her story, promote the book, and get back to her career.

Instead, something happened at every single stop on her book tour.

Women lined up. Dozens of them. Then hundreds.

“My doctor told me I was too young.”

“They said it was stress. It was ovarian cancer.”

“Three years of symptoms before anyone ran a test.”

Her story wasn’t unique. It was everywhere. It was systemic.

Women were being dismissed across every age group, income level, and geography — and some of them were dying because of it.

Fran made a decision: she was not going to let that continue.

In 2007, she launched the Cancer Schmancer Movement, a nonprofit with one clearly defined mission — ensure that women’s cancers are caught at Stage I, when survival rates are highest. She didn’t write a check and step away. She became the organization. She lobbied members of Congress directly. She testified on Capitol Hill. She pushed until lawmakers passed the Gynecologic Cancer Education and Awareness Act into federal law — a national program dedicated to educating women about the warning signs of gynecological cancers.

The vote in Congress was unanimous. Not a single opposing voice.

Cancer Schmancer deployed mobile screening clinics into underserved communities, offering free mammograms and cancer screenings to women who had no other access. Thousands of women were reached. Some of them caught cancers early enough to survive.

She changed how a generation of women thought about their own health — not as patients who wait passively, but as informed consumers with the right to demand answers.

For years, she balanced advocacy with her entertainment career. Acting, voicework, Broadway. But the platform always served the mission.

Then, in 2021, she did something that surprised almost everyone.

She ran for president of SAG-AFTRA — the union representing 160,000 actors, broadcasters, and media professionals across America. Hollywood insiders were skeptical. The entertainment press was uncertain. Fran had never led a major labor organization.

She won anyway.

And in the summer of 2023, she showed everyone exactly why.

After negotiations with major Hollywood studios collapsed — over fair pay, streaming residuals, and the looming threat of artificial intelligence replacing human performers — Fran led SAG-AFTRA into the largest actors’ strike in the industry’s history. Forty thousand actors joined 11,000 striking writers. Hollywood shut down completely. No filming. No premieres. No press tours.

On the first day of the strike, Fran stood before the world’s cameras and delivered a speech that stopped people mid-scroll:

“How they plead poverty — while handing hundreds of millions of dollars to their own CEOs? It is disgusting. Shame on them.”

The internet erupted.

Even the skeptics went quiet.

David Simon, creator of The Wire, who had publicly doubted her leadership, wrote simply: “I’ll confess I thought she was a lost ball in tall grass. I was wrong.”

She showed up on picket lines every day. She refused every offer that fell short. She negotiated without blinking.

After 118 days, the studios gave in.

SAG-AFTRA secured historic gains: substantially higher pay, landmark protections against AI, improved residuals, and better working conditions across the industry. It was the most consequential labor victory in Hollywood’s modern era.

In September 2023, her members re-elected her with 81% of the vote.

Today, Fran Drescher is 68 years old. She has been cancer-free for 26 years. The organization she built from a book tour and a wave of shared grief has shaped national health policy and reached thousands of women who might otherwise never have been screened.

She leads one of the most powerful unions in entertainment.

And all of it — every bit of it — traces back to a single quality she has never been willing to surrender:

The refusal to accept being dismissed.

Eight doctors told her she was fine. She knew they were wrong, and she kept going until someone finally listened.

A medical system told women their symptoms didn’t matter. She changed the law.

Studio executives told actors to accept less. She said no — and won.

Fran Drescher was never just the woman with the famous voice and the iconic laugh.

She was always the woman who refused to be quiet until the room had no choice but to listen.

When the Ship Can’t Dock

Three deaths, a vessel turned away, and what a strange outbreak in the South Atlantic tells us about a much older story.

By Robert W. Malone, MD, MS · Chief Medical Officer, Curativa Bay

This week, I want to start where the news started.

A Dutch-flagged expedition cruise ship called the MV Hondius left Ushuaia, Argentina, more than a month ago, made its planned stops in Antarctica, returned briefly to Ushuaia, sailed north past Saint Helena, and on Sunday anchored off Praia, the capital of Cape Verde, an archipelago off the west coast of Africa. By the time it dropped anchor, three of its passengers were dead. Six more were symptomatic. One British national had been airlifted off and was in critical condition in a Johannesburg ICU. Two crew members were in urgent need of evacuation.

Cape Verde refused permission for the ship to dock.

The official reason — and Cape Verde’s reason was the right one — was the protection of public health. The country’s health authorities sent a medical team aboard to assess the symptomatic crew. They are now monitoring the situation from offshore, and the ship may be redirected to Las Palmas or Tenerife in the Canary Islands, where the docking question will be asked again.

The suspected pathogen is hantavirus. One laboratory-confirmed case so far. Five additional suspected cases. The World Health Organization has been clear that the broader risk to the public is low — hantavirus is rare in humans and, for the strains we usually encounter, is not transmitted easily from person to person. It is most often acquired through contact with rodent excreta.

So why am I, as Chief Medical Officer of a hypochlorous acid company, choosing this story to introduce you to the Curativa Bay Substack?

Because of what the story is actually about — which is not hantavirus.

What the Cruise Ship Is

A cruise ship is a fascinating epidemiological object. It is, in essence, a small floating city — a few hundred or a few thousand people living in close quarters for weeks at a time, eating from shared kitchens, breathing recirculated air, sharing surfaces in narrow corridors, sleeping behind thin walls. When something biological boards that ship, whether it walked on two legs through a customs checkpoint or scurried in on four through a cargo hold, the entire vessel becomes the host environment.

This is why cruise ships have been the location, over the years, of some of the most instructive outbreaks in modern public health. Norovirus on the Diamond Princess. Legionella outbreaks in onboard water systems. Influenza, repeatedly. SARS-CoV-2 famously, on multiple vessels, including the same Diamond Princess that has by now contributed more to our understanding of respiratory pathogen transmission than most universities. The ship turns the population into an unblinded study cohort whether the operators intend it or not.

I want to be careful here. The hantavirus suspected on the Hondius is not, in the ordinary sense, the kind of pathogen we worry about in cruise-ship transmission models. The strains that infect humans most often are acquired through environmental exposure to rodent waste, not by inhaling someone else’s cough. So if you are imagining the Hondius as another Diamond Princess — passengers infecting each other in dining rooms — the analogy is wrong, and Cape Verde’s quarantine decision was about caution and burden of proof rather than about a clear human-to-human chain.

But the Hondius matters for the same reason the Diamond Princess mattered. The ship is the laboratory the world keeps building for itself.

And the fact that we keep building it should make us think hard about what is on board, and what could be on board the next time.
The Pathogens We Actually Worry About

Here is what your epidemiologist friends spend their lunches arguing about. Not the hantavirus on this particular ship. The next outbreak. The one that does spread efficiently, person to person, in close quarters. The one that gets onto a vessel because someone touched a doorknob, or a serving spoon, or a bathroom faucet, and then someone else touched it twenty seconds later.

Norovirus is the classic example. The infectious dose for norovirus is somewhere between ten and a hundred viral particles. Ten. That is a number so small that essentially any contaminated surface in a high-traffic area becomes a transmission vector. Norovirus survives on surfaces for days. It resists most household disinfectants at the concentrations commonly used. It fells cruise ships routinely — every winter, you will read another headline.

Influenza, on a ship, can move through a closed population in days. Respiratory syncytial virus the same. Methicillin-resistant Staphylococcus aureus — MRSA — colonizes surfaces and hands, and on a cruise ship full of older passengers (the demographic skews older for expedition cruises like the Hondius), MRSA infections in wounds or surgical sites can become serious quickly.

And then there is the broader category of communicable disease the public health community calls emerging — the pathogens we do not yet know about, or the ones we know about but have not seen at scale. The next coronavirus. The next H5N1 spillover. The next thing that boards a ship in a port and gets discovered three thousand nautical miles later, when there is no port that will take you.

When a cruise ship ties up at the dock and a passenger steps off, that passenger walks into an airport, into a city, onto a connecting flight to somewhere on the other side of the world. The ship is a node in a much larger network. What gets onboard becomes what gets ashore, and from there, becomes what arrives in your city six weeks later.

This is not catastrophizing. This is just what infectious disease specialists call routine.

Four Conditions, Three Centuries of Unbroken Logic

In every introductory epidemiology course, students learn that for a communicable disease to transmit from one person to another, four things must be true. There must be a pathogen present. The pathogen must be present in sufficient quantity to cause infection — what we call the infectious dose. There must be a route of entry into the new host. And the new host must be susceptible, meaning they do not already have immunity.

If any one of these four conditions fails, transmission fails.

The four-condition model is more than a hundred years old. It has not been overturned. It has not been replaced. It has been refined and quantified, but the underlying logic is the same logic John Snow used in 1854 to take the handle off the Broad Street pump and stop a cholera outbreak in central London. Break one of the four conditions, and the chain collapses.

Disinfection — environmental disinfection, the kind done on doorknobs and dining surfaces and bathroom fixtures and HVAC ductwork — is the most direct intervention against the first two conditions. Reduce the pathogen present. Reduce the quantity below the infectious dose. Break the chain on the surfaces and in the air, before the chain ever reaches a human host.

This is where the rest of the conversation gets interesting. Because for most of the last century, the disinfectants we have used to break that chain have come with their own costs.

The Trouble With Most Disinfectants

Bleach kills almost everything. It also damages tissue, off-gasses chlorine fumes, requires PPE for safe use at concentrations high enough to kill resistant pathogens like norovirus (which requires bleach concentrations as high as 5,000 parts per million to inactivate), and is dangerous to use in occupied spaces.

Quaternary ammonium compounds — the active ingredients in most institutional disinfectant sprays — are positively charged molecules that struggle to penetrate the negatively charged matrix of bacterial biofilms. They are ineffective against non-enveloped viruses like norovirus and parvovirus. They have been associated with occupational asthma in cleaning staff. They leave persistent residue on surfaces. And resistant strains of bacteria have been documented.

Hydrogen peroxide vapor works, but it is a respiratory irritant and requires evacuation of the space being treated.

Alcohol kills most enveloped viruses but evaporates quickly, is flammable, and is largely ineffective against spores and non-enveloped viruses.

Each of these chemistries is useful. None of them is good enough alone. And none of them — none of them — can be safely deployed in occupied spaces while passengers and crew continue going about their business.

This is the gap I want to close.

The Molecule the Body Has Been Using for Six Hundred Million Years

The Curativa Bay Substack is the editorial home of a company built around a single biochemical insight. The molecule the human immune system itself produces to destroy pathogens — hypochlorous acid, or HOCl — is also one of the most powerful broad-spectrum antimicrobial agents we have ever identified. It is produced by your white blood cells, every minute of every day, when those cells encounter a bacterium or a virus or a fungus. The reaction is catalyzed by an enzyme called myeloperoxidase, and the resulting HOCl molecule attacks pathogens through four simultaneous oxidative mechanisms — membrane disruption, enzyme inactivation, nucleic acid oxidation, and biofilm degradation. There is no documented resistance to HOCl in over a century of clinical and industrial study, because there is no single target for evolution to find.

What makes the molecule operationally interesting — and the reason a company exists around it — is that it can now be stabilized outside the body, in solution, at controlled concentrations. It can be sprayed on a wound. It can be fogged into a room. It can be applied to food-contact surfaces, to children’s toys, to door handles in a passenger corridor, to the air handling system of a vessel — all without evacuating the space, without PPE, without leaving toxic residue. After it reacts, it degrades into water and a trace of saline. That is its full byproduct profile.

Norovirus, which requires 5,000 ppm of bleach to kill, is killed by HOCl at concentrations between 160 and 200 ppm. That is a 25- to 31-fold concentration advantage, achieved with a molecule the human body itself produces. The applications across cruise ships, schools, hospitals, food processing, and public-health stockpiles are, in my professional opinion, substantial — and they are precisely the kind of applications where conventional chemistry has fallen short.
Why I’m Writing Here

I came on as Chief Medical Officer of Curativa Bay because, after a long career thinking about countermeasures, I have not encountered another antimicrobial platform that combines this kind of broad-spectrum lethality with this kind of human-tissue safety. The combination is rare in chemistry and common in biology — for good reason. The body has been engineering it for hundreds of millions of years.

The Curativa Bay Substack will be the place where I, and the team here, write regularly about what this molecule means for medicine, public health, biodefense, and the everyday questions of how we protect ourselves and our families from communicable disease. We will cover the science. We will cover the history of antimicrobial chemistry and the failures that brought us to where we are. We will write about wound care, about chronic non-healing infections, about hospital-acquired infections, about pandemic preparedness, about federal stockpiles, about humanitarian deployments. We will write about the institutional and political conversations that shape what countermeasures are available to whom, and at what cost.

We will not catastrophize. The hantavirus outbreak on the Hondius is, in all likelihood, a contained tragedy with a small number of victims and a manageable public-health response. WHO is correct that the broader risk is low. Cape Verde made the right call. The cruise will be redirected. The investigation will continue.

But the Hondius is also, in a smaller way, a flare in the sky. A reminder that ships can carry things across oceans. That ports have the right to say no. That public-health infrastructure depends on the ability to break the chain of transmission before it reaches the next person. And that the chemistry we use to break that chain matters enormously — to the safety of the workers wielding it, to the patients sleeping near it, to the children playing on the surfaces it has touched.

There is a better chemistry for this. Your body has been using it since long before any of us learned to build ships.

I am glad you are here. Subscribe, and stay with us. The next pieces will go deeper — into the four mechanisms HOCl uses to destroy pathogens, into the unsolved problem of biofilm-driven chronic wounds, and into what a serious national biodefense posture would actually look like in 2026.

Thank you for reading.

— Robert W. Malone, MD, MS

Dr. Robert W. Malone is the Chief Medical Officer of Curativa Bay (CuraClean Technologies). He is a physician, scientist, and the inventor of foundational mRNA vaccine technology. He has served on multiple biotechnology and biodefense advisory bodies and writes regularly on pandemic preparedness, medical countermeasures, and public-health policy.