No safe level of alcohol consumption, major study concludes

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Giving up drinking completely is the only way to avoid the health risks associated with alcohol, according to a major new study.

Alcohol-related problems kill around 7 per cent of men and 2 per cent of women every year, and drinking is the leading cause of death and disability for people aged 15-49.

Though previous research has shown moderate levels of drinking may protect against heart disease, the new study concluded any supposed boosts to health are massively offset by the costs.

Alcohol sales would ‘fall 38% if drinkers kept within guidelines’
The researchers covered 195 countries between 1990 and 2016, and amassed data from hundreds of other studies.

“With the largest collected evidence base to date, our study makes the relationship between health and alcohol clear – drinking causes substantial health loss, in myriad ways, all over the world,” said Dr Max Griswold from the Institute for Health Metrics and Evaluation, one of the study’s lead authors.

They estimated that one drink a day increases the risk of developing an alcohol-related diseases including cancer, diabetes and tuberculosis by 0.5 per cent. This shot up to 7 per cent for those having two drinks a day, and 37 per cent for five drinks.

The study defined one drink as 10g of pure alcohol, equivalent to a can of beer or a shot of spirits.

The findings emerge after another report found the drinks sector in the UK relies on people drinking above government limits for nearly 40 per cent of its revenues.

Official guidelines currently state that to keep alcohol health risks low, it is safest to avoid consuming more than 14 units a week – about seven pints of lager – on a regular basis.

However, the UK’s chief medical officers have previously stated that despite this allowance, there is “no safe level of alcohol consumption” – a point that has been reinforced by this study.

“There is a compelling and urgent need to overhaul policies to encourage either lowering people’s levels of alcohol consumption or abstaining entirely,” said Dr Emmanuela Gakidou, who also worked on the new research.

“The myth that one or two drinks a day are good for you is just that – a myth. This study shatters that myth.”

The findings were broadly welcomed by scientists and NGOs as a decisive statement on the impact drinking has on society.

Dr Tony Rao, a psychiatrist at King’s College London who was not involved in the study, commended the effort to unravel the complicated relationship between alcohol and health.

“We can now be more confident that there is no safe limit for alcohol when considering overall health risks,” he said.

The authors of the research, published in the journal The Lancet, noted their efforts did not take in all aspects of alcohol consumption. Ample data were not available for alcohol-related violence and traffic accidents, or for the illicit production and consumption of alcoholic drinks.

The findings have ramifications for public health policy, and have prompted calls for government action to make a serious dent in the population-level consumption of alcohol.

“These diseases of unhealthy behaviours, facilitated by unhealthy environments and fuelled by commercial interests putting shareholder value ahead of the tragic human consequences, are the dominant health issue of the 21st century,” said Dr Robyn Burton from King’s College London.

“The solutions are straightforward: increasing taxation creates income for hard-pressed health ministries, and reducing the exposure of children to alcohol marketing has no downsides.”

However, others were more measured in their response to the new findings, and emphasised the need to weigh them up against the benefits of alcohol.

“Given the pleasure presumably associated with moderate drinking, claiming there is no ‘safe’ level does not seem an argument for abstention,” said Professor David Spiegelhalter, a statistician who specialises in understanding of risk at the University of Cambridge.

“There is no safe level of driving, but government do not recommend that people avoid driving.

“Come to think of it, there is no safe level of living, but nobody would recommend abstention.”

https://www.independent.co.uk/news/health/alcohol-drinking-no-safe-level-health-heart-disease-cancer-study-a8505181.html

Environmentally-Caused Disease Crisis? Pesticide Damage to DNA Found ‘Programmed’ Into Future Generations

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When Dr. Paul Winchester, a pediatrician, moved to Indiana from Colorado in 2002, he noticed something disturbing—a high number of birth defects.

“I was used to the number of birth defects I should see in a community hospital, and I saw many more in Indiana,” said Winchester, who is medical director of the Neonatal and Intensive Care Unit at St. Francis Hospital in Indianapolis.

Winchester decided to investigate the reason for the higher numbers of birth defects. His research zeroed in on the herbicide atrazine, one of the most widely used herbicides in the U.S. and the most commonly detected pesticide in U.S. drinking water.

Winchester and several other researchers including Michael Skinner, professor of biology at Washington State University’s Center for Reproductive Biology, conducted a study to see if there was a link between atrazine in drinking water and birth defects.

Studies have found that atrazine is an endocrine disruptor, a substance that can alter the human hormonal system. Atrazine was banned by the European Union because of its persistent groundwater contamination.

In their study, Winchester and his team found that concentrations of atrazine in drinking water were highest in May and June when farmers sprayed their fields with the herbicide. They also found that birth defects peaked during the same months indicating a close correlation.

“We plotted water concentrations and birth defects, and they fit like a hat,” Winchester said.

https://www.ecowatch.com/generational-harm-of-pesticides-2596453994.html

https://www.ecowatch.com/generational-harm-of-pesticides-2596453994.html

Destructive Mechanism That Blocks the Brain from Knowing When to Stop Eating Identified

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I would be very interested to know what fats the mice were fed as this goes completely against the ketogenic diet.

I also find it interesting that the focus in the article is on how to find a drug that will solve it rather than what can we do to alter our diet and lifestyle to preent the problem. – Tom

Summary: Researchers report mice fed a high fat diet produce an enzyme called MMP-2, which results in leptin being blocked from binding to its receptors. This, they report, prevents neurons from signaling that the stomach is full. The study suggests blocking MMP-2 may help people with obesity to lose weight.

An international team of researchers has uncovered a destructive mechanism at the molecular level that causes a well-known phenomenon associated with obesity, called leptin resistance.

They found that mice fed a high-fat diet produce an enzyme named MMP-2 that clips receptors for the hormone leptin from the surface of neuronal cells in the hypothalamus. This blocks leptin from binding to its receptors. This in turn keeps the neurons from signaling that your stomach is full and you should stop eating.

This is the first time that a destructive molecular mechanism has been observed and described.

https://neurosciencenews.com/leptin-obesity-overeating-9739/