Synthetic caffeine IS NOT chemically identical to “naturally occurring caffeine” because it was never scientifically proven to exist in the first place.
Caffeine was ALLEGEDLY “discovered” by German chemist Friedrich Ferdinand Runge back in 1819–how did he discover it?
He took coffee beans and made them into a powder, added boiling water to the powder, and then added chloroform or ether, and potassium hydroxide—after adding all of those, he claimed that the final substance he had was isolated caffeine from the coffee beans.
He conducted ZERO controls for his experiment—it’s completely pseudoscientific.
This experiment laid the foundation for all modern “caffeine” research.
Now by saying this, I’m not saying that some people don’t get increased energy, or enhanced concentration and focus after consuming coffee. I’m just pointing out the holes in his experiment for allegedly discovering caffeine—effects do not prove a cause!
(Tom: I think he would have been better saying caffeine has not been proven to exist rather than that it does not exist. It may still exist even though the method for isolating what was called caffeine was unscientific and invalid.)
Optimizing your vitamin D to a level between 50 nanograms per milliliter and 80 ng/mL is probably one of the simplest, least expensive and most foundational strategies to sustain your health. In Europe and Canada, the blood level you’re looking for is 150 to 200 nanomoles per liter.
If for whatever reason you can’t get enough sun exposure to reach that ideal level, consider taking an oral vitamin D3 supplement. As a rule, adults who don’t get sun exposure will need about 8,000 IUs a day. If you’re obese, you’ll want to increase that a little bit, because vitamin D is a fat-soluble vitamin, so it’s easily stored in your fat.
That said, sun exposure also has several other health benefits that are unrelated to vitamin D production — and which cannot be obtained by swallowing a vitamin D supplement.
For example, the near-infrared rays in sunlight create structured water, also known as EZ water, which acts a bit like a battery, in that it gets charged with energy. This structured gel-like water is important for cellular integrity. It also enhances the ability of red blood cells to flow through your capillaries. It also plays an important role in the energy distribution within your body.
Another major health benefit of sun exposure is the production of melatonin in your mitochondria. This too is produced by the near-infrared in sunlight. Melatonin is a profoundly effective antioxidant, but it also causes your body to produce other endogenous antioxidants, such as glutathione.
It’s important to have high quantities of subcellular mitochondrial melatonin to help regulate your body’s oxidative stress. You can learn more about this from my interview with Dr. Russel Reiter.
Sunlight also allows vitamin A to be converted into retinoids, which is the active form, and vitamin A is almost as important as vitamin D. Another hormone that’s important is testosterone. If you get sufficient sun exposure it will increase your testosterone levels. Men obviously have and need more testosterone, but it’s also an important sex hormone for women.
I recognise a lot of what I share is contrary to the accepted view of society and as such may put my data into the category of “fringe” or “extreme”. So it is heartening to be able to share with you mainstream acceptance of some of the more radical ideas, that medical research is most often little more than pharma paid propaganda that bears little to no resemblance to truth.
New research shows mitochondrial dysfunction in T cells leads to immune system decline, affecting the body’s ability to fight infections and cancer
The study identifies glycolysis as an inefficient way to produce energy, and the reactive oxygen species (ROS) produced in the process damage T cells
The findings suggest reversing mitochondrial damage could improve immune response and cancer therapies
Excess linoleic acid (LA) intake and estrogen dominance are major contributors to mitochondrial dysfunction
Strategies that will improve your mitochondrial function include lowering your LA intake, reducing stress and taking a niacinamide supplement
Immune system weakening has long been attributed to aging and poor lifestyle choices, but according to an October 2023 study1 in Nature Communications, the key reason for this immune system decline is dysfunctional mitochondria, your cells’ powerhouses, particularly the mitochondria found in T cells (a type of immune cell).
When the mitochondria don’t work well, the T cells don’t have the energy required to perform their functions, which leads to a decline in immune system function. This in turn, results in an inability to ward off both acute infections and chronic diseases. As reported by Medical Xpress:2
“… In the immune system, chronic infections and the defense against tumors often lead to the phenomenon of T cell exhaustion: In this process, the T lymphocytes gradually lose their function, which impairs their responses against cancer and infections …
This research has now shown that the exhaustion process is significantly influenced by … the mitochondria. When mitochondrial respiration fails, a cascade of reactions is triggered, culminating in the genetic and metabolic reprogramming of T cells, a process that drives their functional exhaustion.”
The good news, which was confirmed by the featured study, is that this decline can be reversed with treatments that target mitochondrial function.
Poor Mitochondrial Function Can Lead to T Cell Exhaustion
In simple terms, when your body fights an infection, immune cells called CD8+ T cells transform into cytotoxic T lymphocytes (CTLs) to destroy the infected cells. This transformation requires changes in gene expression, cell structure and energy use.
However, in long-lasting infections or cancer, the T cells can become worn out or “exhausted,” losing their effectiveness. This exhaustion is related to energy problems within the cells, particularly in the mitochondria. Researchers are now exploring how fixing these energy problems can rejuvenate exhausted T cells, thereby improving cancer treatments. Bioenergetic researcher Georgi Dinkov comments on these findings:3
“So far, the decline in immune function seen in aging had been explained with the simplistic ‘wear and tear’ concept, and when immunodeficiency occurs in younger people it is ascribed either to genetic vulnerability or lifestyle choices such as alcohol/drug consumption.
In other words, to this day medicine does not seem to have a good grip on why immune function fails in aging and disease, and what (if anything) can be done to prevent that.
The study … demonstrates that the direct cause of immune decline is rather simple — decline in mitochondrial function (OXPHOS). When T-cells (immune cells produced by the thymus) have dysfunctional mitochondria, they have to rely exclusively on glycolysis for energy production.
Glycolytic production of energy is insufficient to support proper T-cell differentiation and activity, and in fact can lead to T-cell damage or even death due to the high amount of reactive oxygen species (ROS) produced when glycolysis is the main mode of energy production.
The study also demonstrated that such mitochondrial dysfunction is a necessary and sufficient condition for immune decline to occur (aka T-cell ‘exhaustion’) and that the decline was reversible when mitochondrial function was restored pharmacologically.”
Glucose Metabolism 101
So, what is “glycolytic production of energy” and why is it so detrimental? All dietary carbohydrates are digested and broken down into glucose, a type of sugar. Glucose, in turn, can be metabolized (burned) for fuel using two different pathways, as illustrated below.
First, the glucose is metabolized into pyruvate. The pyruvate can then either enter the glycolysis pathway in the cytoplasm of the cell and produce lactate, or it can be converted into acetyl-CoA and shuttled to the mitochondrial electron transport chain.
Cancer cells are notorious for using the glycolysis pathway — the same pathway glucose goes through when your glucose metabolism is impaired in mitochondria. Basically, this is the pathway your body uses whenever it reaches its limit to how much ATP can be produced in the mitochondria (which is the most efficient and least damaging way to produce energy).
The Downstream Hazards of Glycolysis
While the glycolysis pathway is wonderful when you need quick fuel, if this is the primary way you burn glucose, then you are in a constant state of activating stress hormones and promoting insulin resistance and diabetes, which in turn creates loads of lactate as a waste product instead of healthy carbon dioxide (CO2) and metabolic water.
Lactate increases reductive stress, which causes reverse electron flow in the mitochondria and increases the ROS to 3% to 4%, which is 30 to 40 times more than when glucose is burned in the mitochondria. This elevated ROS production is what causes T cell damage and death.
What’s more, glycolysis generates only two ATP for every molecule of glucose, which is 95% less energy than would be generated if the glucose was metabolized in your mitochondria.
The Devil’s in the Details
Now, you’ve probably heard that sugar promotes cancer, because cancer cells preferentially use glycolysis. However, it’s a mistake to think that all glucose uses the glycolysis pathway. As illustrated above, glucose can also be burned in the electron transport chain of the mitochondria, which is the most efficient way to produce energy.
So, when it comes to the “sugar fuels cancer” issue, it’s important to make a distinction between the sources of the carbs. While it is technically accurate to call all carbs sugar, there is a radical difference in the source of the carbs — ripe whole fruits versus starches, for example, and whole fruits versus refined processed sugar (ex: table sugar and high fructose corn syrup).
Refined sugars, as well as many starches, are a common cause of endotoxin production in your gut, which destroys mitochondrial function and results in cancer metabolism, whereas the fructose present in whole foods does not typically result in the production of endotoxin.
This is one of the primary differences between refined sugar and fructose from ripe fruit and helps explain why refined sugars fuel cancer while natural fructose does not. So, to be clear, it’s not sugar that is driving the cancer process per se. It’s really rooted in mitochondrial dysfunction, and fatty acid oxidation (the metabolism of fats instead of glucose) is part of what causes that dysfunction.
You Want to Burn Glucose in Your Mitochondria
For a long time, I believed fats burned “cleaner” than carbs — that’s one of the “selling points” for keto — but I’ve since realized we had it backward. Glucose, when burned in the mitochondria, actually burns far cleaner than fat.
So, it’s important to get your macronutrient ratios right, because if the glucose you eat is constantly shuttled into glycolysis, you’re fueling cancer. At the same time, the fat you consume ends up in fat storage rather than being used up for fuel.
Ultimately, you want to burn glucose in your mitochondria, and the way you ensure that is by keeping your dietary fat intake below 35% of your total calories. The reason for this is because when fat intake is too high, glucose gets shuttled into glycolysis. For a more in-depth explanation of this metabolic switch, see “Understanding the Randle Cycle.”
If you’re insulin resistant, which means you’re metabolically inflexible, that threshold may be closer to 20% or even 10%. So, if you’re insulin resistant, you’ll want to significantly lower your fat intake until your insulin resistance is resolved. Then you can increase it to 30%.
Dysfunctional T Cells and Cancer Cells Use Glycolysis
The reason cancer cells use the glycolysis pathway is because they have severely dysfunctional mitochondria. The mitochondria are so damaged, they cannot burn glucose. As a result, the cancer cells must rely on the backup system, glycolysis, to survive. This is what the Warburg Effect is all about.
Likewise, when the mitochondria inside T cells become dysfunctional, the T cells are forced to rely on glycolysis for energy production, which is what causes immune system weakening and failure.
As mentioned in the featured study, T cell exhaustion is a feature of cancer, which makes sense when you consider that it’s all tied to mitochondrial dysfunction. The cancer starts because the mitochondria in cells are severely damaged, and as the disease progresses, the mitochondria in the T cells begin to fail as well.
Since mitochondrial dysfunction is at the heart of it all, the most effective strategy is to use metabolic therapies that address why the cells are unable to oxidize (burn) sugar in the mitochondria. Once you fix the mitochondria so that they can generate sufficient energy again, then the cancer will typically regress and immune function will be restored, as they no longer need to rely on glycolysis.
What Causes Mitochondrial Dysfunction?
There are four primary contributors to mitochondrial dysfunction:
Excess linoleic acid (LA) intake
Estrogen dominance
Electromagnetic field (EMF) exposure
Endotoxin — Refined sugars and many starches are more likely to cause gut dysbiosis that leads to the production of endotoxin. This endotoxin is one of the factors that destroys mitochondrial function, resulting in the Warburg Effect (cancer metabolism), where glucose is burned through glycolysis
These all play major roles, but excess LA and estrogen dominance, I believe, are the leading contributors to mitochondrial dysfunction. This is largely because LA and estrogen negatively impact your body in similar ways. They both:
Increase free radicals that cause oxidative stress and damage your mitochondria’s ability to produce energy.
Increase calcium intake inside the cell that causes an increase in nitric oxide and superoxide that increases peroxynitrite that also increases oxidative stress.
Cause an increase in intracellular water causing your body to retain water.
Slow down your metabolic rate and suppress your thyroid gland.
Nearly everyone in the developing world has 10 times the amount of LA in their tissues than their ancestors of 100 years ago had. This polyunsaturated fat (PUFA) is very susceptible to oxidative damage, and produces free radicals like reactive aldehydes in your body that destroy your mitochondria.
These toxic metabolites of LA create enormous amounts of reductive stress as a result of electrons building up in the ETC and blocking the forward movement of electrons to complex IV and V to create ATP. And, because LA is embedded in the inner mitochondrial membrane, it gets damaged and leaks protons that normally build up in the inner mitochondrial space.
This proton gradient is responsible for driving the nano motor in complex V to create ATP. Both processes combine to shut down and ultimately prematurely destroy the mitochondria. Also, when you eat starches, they can end up feeding endotoxin-producing bacteria in your intestine, and endotoxin is a potent mitochondrial poison.
Solutions
In closing then, some of the key solutions, if you want to improve or restore your mitochondrial function, would be to:
Lower your LA intake as low as possible by avoiding processed foods, seed oils, chicken, pork, seeds and nuts.
Make sure you’re eating healthy carbs such as ripe fruit, raw honey and maple syrup.
Decrease lactate production and increase carbon dioxide, as they have opposing effects.4 You can learn more about this in “The Biology of Carbon Dioxide.”
Reduce your stress, as chronic stress promotes cortisol release, which is a potent suppressor of mitochondrial function and biogenesis. Progesterone can be quite helpful here, as it’s a potent cortisol blocker. You can learn more about this in “What You Need to Know About Estrogen and Serotonin.”
Take supplemental niacinamide, as your mitochondria cannot make energy without it. I recommend taking 50 mg of niacinamide three times a day.
1. Increase your TUT – Time Under Tension
Perform exercises at a slower rate rather than faster and heavier
Taking 40-60 seconds to complete a rep increases muscle 51% more
2. Stop Starving Yourself
Caloric Deficit for too long initiates starvation mode – slows metabolism and increases fat storage.
Start Carb cycling
Low carb day
Moderate carb day
High carb day
3. Stop doing traditional cardio at a constant pace
3 days a week for 15 minutes a day do HIT – High Intensity Interval Training
Doing this burns calories for up to 48 hours after HIT – the Afterburn Effect.
While we still live in an insane society where others cannot be trusted it behooves us to be able to protect ourselves, our families and friends. To prevent us from being able to do that is tyrannical oppression.
I recently saw a report of a study that found 70% of long Covid sufferers had never had Covid, they had only received the jab.
To aid those tricked/coerced into getting the jab as well as those suffering from symptoms of shedding after being exposed to the jabbed, I have done my best to compile a Jab Recovery Protocol from the various sources I have seen: https://www.tomgrimshaw.com/tomsblog/?p=35644
(Tom: We presently have ring-side seats on the modern equivalent of “the fall of Rome”.
The writer states: “The rot has so deeply infested our nation that at least one congressman has admitted that there is no normal, procedural way to set things right. “
As I have said before: “As I see it this intentional destruction, done with full complicity of the infiltrated Federal institutions, is best countered by the ordinary man and woman in the street starting at the local level to reclaim control over their school boards, local councils then building momentum from there to state governments and institutions that can nullify unconstitutional Federal regulations.
If you want to save The US of A, better start now! Get some mates together and strategise how you will take back your street, your suburb/town/city and state from the uniparty representatives that do not serve your interests.”)
In the 1930s, when Hitler was rising to power, there were some Germans who correctly foresaw that the end result would be catastrophe for Europe and for the German people, as well as for Jews and others. They attempted to persuade their fellow Germans to oppose the impending dictatorship — as history tragically shows, to no avail.
Anecdotes include that of a man who escaped Germany with only one suitcase, planning to return in a few days, after people who supported Hitler regained their sanity and ousted him. Another concerns a man who eventually gave in to his son’s persistent requests to be permitted to join the Nazi Party. He felt that by doing so, his son at least would avoid persecution by the brown-shirted minions of the regime. In doing so, he handed his son over to doom. It is questionable whether father or son survived the resulting war, the war that skeletonized Berlin and left its people starving, entirely reliant on the mercies of those whom they had, until then, tormented.
Key to all of this in the 1930s was the false perception, renewed each day, that the Nazi government had gotten so bad that matters could not possibly get any worse. They just had to turn around and get back to a normal, civilized society. After all, just how bad could things get? Could they possibly lead to a worldwide war? (Japan’s Pacific ambitions relied heavily on, and were encouraged by, the expectation that Germany would defeat the British Empire and thereby expel it from Asia.) And the idea of millions dying in “death camps” seemed preposterous in 1933. Only barbarians could enact such a policy. Surely, civilized Germany could never, ever do such a thing.
Is it fair to compare modern America to the Germany of the era of 1933–45?
Decide for yourself. In America, the so-called “Free Speech” movement of the 1960s quickly morphed into the practice of censorship by shouting down speakers with whom the left disagrees. How far can that get? Racial civil rights, a good thing, eventually was deceptively adapted to women’s rights, gay rights, and even “animal rights.” Women’s rights became the right to kill millions of unborn children. Racial civil rights became the debilitations of multi-generational welfare for life. Add to all these the right of criminals, even murderers, to be released without punishment. Okay, no farther.
But farther there was.
The right of gays to be “left alone,” and then to marry each other, eventually became the right of homosexuality advocates to teach small schoolchildren the sexual practices of sodomy. No, this can’t be true! No one could have foreseen that a president of the United States, abetted by the entire Democrat party, and the courts, would use taxpayer money to bring children into “sex change” clinics to mutilate them, to permanently destroy their ability to grow into their natural sex. One would have been deemed insane to predict such a thing.
We have in the Oval Office an increasingly senile puppet whose handlers not only permit millions of illegal aliens to flood our nation, swelling our census with future representatives who will represent them, not us — not only permit, but actually pay for their lawless border-crossing with our tax dollars.
We now have in Congress people who openly acquiesce to foreign powers sworn to destroy America. We have corporate boards of directors who despise the ordinary hardworking citizen and who openly sneer at our flag and ridicule the idea of selfless patriotism. The rot has so deeply infested our nation that at least one congressman has admitted that there is no normal, procedural way to set things right.
We used to trust that election officials would not rig elections.
For decades, the question has been asked: when will Americans wake up? They have yet to do so, and the nightmare not only continues, but gets worse. Just as in 1933 Germany, antisemitism has become a dreadful fact of the political scene, especially on American college campuses. How far will it go?
Unlike in twentieth-century Germany, there are a few people in power who recognize, and oppose, the present trend toward an American tyranny. Governor Abbott of Texas is one, and he has the explicit support of twenty-five other governors. We have a tradition of independence, of private weapons ownership, and of refusing to be silenced.
Will these few, citizens and governors, be enough? Or will we sink into the mire that swallowed the mighty epitome of civilization that Germany once had been? There will be no one to come to our aid — only foreign armies to trample us. Will we allow our children to be enslaved?
As President Reagan once said, there are no easy choices, but there are simple ones.
