I would be very interested to know what fats the mice were fed as this goes completely against the ketogenic diet.
I also find it interesting that the focus in the article is on how to find a drug that will solve it rather than what can we do to alter our diet and lifestyle to preent the problem. – Tom
Summary: Researchers report mice fed a high fat diet produce an enzyme called MMP-2, which results in leptin being blocked from binding to its receptors. This, they report, prevents neurons from signaling that the stomach is full. The study suggests blocking MMP-2 may help people with obesity to lose weight.
An international team of researchers has uncovered a destructive mechanism at the molecular level that causes a well-known phenomenon associated with obesity, called leptin resistance.
They found that mice fed a high-fat diet produce an enzyme named MMP-2 that clips receptors for the hormone leptin from the surface of neuronal cells in the hypothalamus. This blocks leptin from binding to its receptors. This in turn keeps the neurons from signaling that your stomach is full and you should stop eating.
This is the first time that a destructive molecular mechanism has been observed and described.
https://neurosciencenews.com/leptin-obesity-overeating-9739/