{"id":67439,"date":"2026-10-02T17:32:44","date_gmt":"2026-10-02T07:32:44","guid":{"rendered":"https:\/\/www.tomgrimshaw.com\/tomsblog\/?p=67439"},"modified":"2026-10-02T17:32:44","modified_gmt":"2026-10-02T07:32:44","slug":"acacetin-inhibiting-spike-protecting-the-endothelium-and-taming-the-macrophage","status":"publish","type":"post","link":"https:\/\/www.tomgrimshaw.com\/tomsblog\/?p=67439","title":{"rendered":"Acacetin: Inhibiting Spike, Protecting the Endothelium and Taming the Macrophage"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-67440\" src=\"https:\/\/www.tomgrimshaw.com\/tomsblog\/wp-content\/uploads\/2026\/10\/Acacetin_Actions.jpg\" alt=\"Acacetin Actions\" width=\"732\" height=\"488\" srcset=\"https:\/\/www.tomgrimshaw.com\/tomsblog\/wp-content\/uploads\/2026\/10\/Acacetin_Actions.jpg 732w, https:\/\/www.tomgrimshaw.com\/tomsblog\/wp-content\/uploads\/2026\/10\/Acacetin_Actions-300x200.jpg 300w\" sizes=\"auto, (max-width: 732px) 100vw, 732px\" \/><\/p>\n<p>The article: \u00a0<a href=\"https:\/\/wmcresearch.substack.com\/p\/friday-hope-acacetin-inhibiting-spike\">https:\/\/wmcresearch.substack.com\/p\/friday-hope-acacetin-inhibiting-spike<\/a><\/p>\n<p>(Tom: The article is heavy on medical data and light on the sources and use of those sources so I asked Grok.com:<br \/>\nWhat are the highest natural sources of acacetin?<\/p>\n<p>Grok replied:<br \/>\nThe highest natural sources of acacetin (a flavone also known as linarigenin or 5,7-dihydroxy-4&#8242;-methoxyflavone) are the flowers and flower heads of specific herbs and plants, where it occurs primarily in glycoside forms.<\/p>\n<p>Exact quantitative data (e.g., mg\/g or mg\/100g) is limited in public literature, but the richest sources\u2014based on traditional use, phytochemical isolation, and research\u2014are ranked below by concentration\/ubiquity for dietary consumption:<\/p>\n<p>Top Sources (Highest Concentration)<br \/>\n&#8211; Chamomile flowers (Matricaria chamomilla or Chamomela nobile): Dried flower heads are repeatedly cited as among the highest dietary sources of acacetin. Brewed as tea or used as an infusion; this is one of the most accessible and concentrated ways to consume it naturally.<br \/>\n&#8211; Chrysanthemum (Dendranthema morifolium \/ Chrysanthemum indicum): Dried blossoms are rich in acacetin (often studied in extracts); a staple in East Asian herbal teas with high levels reported.<br \/>\n&#8211; Damiana (Turnera diffusa): Leaves are heavily researched for high acacetin content; traditionally brewed as a tea or used in extracts.<\/p>\n<p>Other Notable Sources (Good but Lower or More Modest Amounts)<br \/>\n&#8211; Black locust flowers (Robinia pseudoacacia): Historically the original isolation source (used by early chemists); flower clusters are aromatic and edible, though not commonly brewed as tea.<br \/>\n&#8211; Artichoke (Cynara scolymus): Edible buds and specialized leaf extracts contain measurable levels.<br \/>\n&#8211; Fresh herbs\/spices (lower concentration): Rosemary, thyme, oregano, and parsley leaves (Petroselinum crispum) contain detectable amounts.<br \/>\n&#8211; Citrus peels (modest): Especially bitter orange zest; not a primary source.<\/p>\n<p>Acacetin is lipophilic (fat-soluble) and often occurs as glycosides, so gentle simmering or steeping in hot water (avoiding prolonged boiling) maximizes extraction. Pairing with healthy fats (e.g., in ghee or with meals) can improve absorption.<\/p>\n<p>These plants are widely available as teas, supplements, or fresh ingredients\u2014chamomile and chrysanthemum teas are particularly easy starting points. Always check for quality (organic, tested) and consult a healthcare provider before using any herbals, especially if you have conditions or take medications. The substack article highlights acacetin\u2019s potential benefits, but natural dietary intake via these sources provides a gentle, traditional approach.)<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The article: \u00a0https:\/\/wmcresearch.substack.com\/p\/friday-hope-acacetin-inhibiting-spike (Tom: The article is heavy on medical data and light on the sources and use of those sources so I asked Grok.com: What are the highest natural sources of acacetin? Grok replied: The highest natural sources of acacetin (a flavone also known as linarigenin or 5,7-dihydroxy-4&#8242;-methoxyflavone) are the flowers and flower heads &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.tomgrimshaw.com\/tomsblog\/?p=67439\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Acacetin: Inhibiting Spike, Protecting the Endothelium and Taming the Macrophage&#8221;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5,6,133],"tags":[],"class_list":["post-67439","post","type-post","status-publish","format-standard","hentry","category-general-interest","category-health-tips","category-vaccines"],"_links":{"self":[{"href":"https:\/\/www.tomgrimshaw.com\/tomsblog\/index.php?rest_route=\/wp\/v2\/posts\/67439","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.tomgrimshaw.com\/tomsblog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.tomgrimshaw.com\/tomsblog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.tomgrimshaw.com\/tomsblog\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.tomgrimshaw.com\/tomsblog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=67439"}],"version-history":[{"count":1,"href":"https:\/\/www.tomgrimshaw.com\/tomsblog\/index.php?rest_route=\/wp\/v2\/posts\/67439\/revisions"}],"predecessor-version":[{"id":67441,"href":"https:\/\/www.tomgrimshaw.com\/tomsblog\/index.php?rest_route=\/wp\/v2\/posts\/67439\/revisions\/67441"}],"wp:attachment":[{"href":"https:\/\/www.tomgrimshaw.com\/tomsblog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=67439"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.tomgrimshaw.com\/tomsblog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=67439"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.tomgrimshaw.com\/tomsblog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=67439"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}