![\"Magnesium](\"https:\/\/www.tomgrimshaw.com\/tomsblog\/wp-content\/uploads\/2026\/09\/Magnesium_Caps.jpg\")
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A powerful clinical study shows that pennies worth of magnesium a day provides an effective, safe, affordable alternative to dangerous and relatively ineffective pharmaceutical antidepressants.<\/strong><\/em><\/p>\n Depression is one of the most widely diagnosed conditions of our time, with over 3 million cases in the U.S. every year, and 350 million believed affected worldwide.1 Conventional medicine considers antidepressant drugs first-line treatments, including the newly approved injected postpartum drug<\/a><\/strong> costing $34,000 a treatment, to the tune of a 16 billion dollars<\/a><\/strong> in global sales by 2023. Despite their widespread use, these drugs are fraught with a battery of serious side effects, including suicidal ideation and completion<\/a><\/strong> — the last two things you would hope to see in a condition that already has suicidality as a co-morbidity. For this reason alone, natural, safe, and effective alternatives are needed more than ever before.<\/p>\n While research into natural alternatives for depression<\/a><\/strong> is growing daily — GreenMedInfo.com’s Depression database<\/a><\/strong> contains 647 studies on over 100 natural substances that have been studied to prevent or treat depression — it is rare to find quality human clinical research on the topic published in well-respected journals. That’s why a powerful study published in PLOS One titled, “Role of magnesium supplementation in the treatment of depression: A randomized clinical trial<\/a><\/strong>,” is so promising. Not only is magnesium safe, affordable, and easily accessible, but according to this recent study, effective in treating mild-to moderate symptoms of depression.<\/strong><\/p>\n While previous studies have looked at the association between magnesium and depression,2-7 this is the first placebo-controlled clinical study to evaluate whether the use of over-the-counter magnesium chloride (248 mg elemental magnesium a day for 6 weeks) improves symptoms of depression.<\/p>\n