{"id":63949,"date":"2026-03-18T11:14:17","date_gmt":"2026-03-18T00:14:17","guid":{"rendered":"https:\/\/www.tomgrimshaw.com\/tomsblog\/?p=63949"},"modified":"2026-03-18T11:14:17","modified_gmt":"2026-03-18T00:14:17","slug":"the-spike-protein-ferritin-and-long-covid-additional-damage-to-the-microvasculature-2","status":"publish","type":"post","link":"https:\/\/www.tomgrimshaw.com\/tomsblog\/?p=63949","title":{"rendered":"The Spike Protein, Ferritin and Long COVID: Additional Damage to the Microvasculature"},"content":{"rendered":"<p>The Spike Protein appears to induce massive release of iron from Ferritin, damaging the microvasculature much like after mini strokes.<\/p>\n<p>I would like to discuss an additional mechanism of microvascular damage today that the Spike Protein may induce. This mechanism can also help to explain the neurological symptoms of Long COVID \u2013 and why it resembles post stroke conditions. This mechanism starts with \u2013 the Endothelium. Brain endothelial cells contain high amounts of Ferritin.<\/p>\n<p>Iron mediates endothelial cell damage and blood-brain barrier opening in the hippocampus after transient forebrain ischemia in rats<br \/>\nhttps:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3047193\/<\/p>\n<p>SARS-CoV-2 Spike Protein Induces Time-Dependent and Brain-Region-Specific Alterations in Ferroptosis Markers: A Preliminary Study in K18-hACE2 Mice<br \/>\nhttps:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12897609\/<\/p>\n<p>Serum Ferritin Levels Are Associated with Vascular Damage in Patients with Nonalcoholic Fatty Liver Disease.<br \/>\nhttps:\/\/ashpublications.org\/blood\/article\/114\/22\/5098\/77164\/Serum-Ferritin-Levels-Are-Associated-with-Vascular<\/p>\n<p>Serum ferritin level during hospitalization is associated with Brain Fog after COVID-19 https:\/\/www.nature.com\/articles\/s41598-023-40011-0<\/p>\n<p>Finish reading:\u00a0https:\/\/open.substack.com\/pub\/wmcresearch\/p\/the-spike-protein-ferritin-and-long<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The Spike Protein appears to induce massive release of iron from Ferritin, damaging the microvasculature much like after mini strokes. I would like to discuss an additional mechanism of microvascular damage today that the Spike Protein may induce. This mechanism can also help to explain the neurological symptoms of Long COVID \u2013 and why it &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.tomgrimshaw.com\/tomsblog\/?p=63949\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;The Spike Protein, Ferritin and Long COVID: Additional Damage to the Microvasculature&#8221;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5,6,133],"tags":[],"class_list":["post-63949","post","type-post","status-publish","format-standard","hentry","category-general-interest","category-health-tips","category-vaccines"],"_links":{"self":[{"href":"https:\/\/www.tomgrimshaw.com\/tomsblog\/index.php?rest_route=\/wp\/v2\/posts\/63949","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.tomgrimshaw.com\/tomsblog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.tomgrimshaw.com\/tomsblog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.tomgrimshaw.com\/tomsblog\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.tomgrimshaw.com\/tomsblog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=63949"}],"version-history":[{"count":1,"href":"https:\/\/www.tomgrimshaw.com\/tomsblog\/index.php?rest_route=\/wp\/v2\/posts\/63949\/revisions"}],"predecessor-version":[{"id":63950,"href":"https:\/\/www.tomgrimshaw.com\/tomsblog\/index.php?rest_route=\/wp\/v2\/posts\/63949\/revisions\/63950"}],"wp:attachment":[{"href":"https:\/\/www.tomgrimshaw.com\/tomsblog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=63949"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.tomgrimshaw.com\/tomsblog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=63949"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.tomgrimshaw.com\/tomsblog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=63949"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}