{"id":63877,"date":"2026-03-07T13:17:26","date_gmt":"2026-03-07T02:17:26","guid":{"rendered":"https:\/\/www.tomgrimshaw.com\/tomsblog\/?p=63877"},"modified":"2026-03-07T13:17:26","modified_gmt":"2026-03-07T02:17:26","slug":"broken-mitochondria","status":"publish","type":"post","link":"https:\/\/www.tomgrimshaw.com\/tomsblog\/?p=63877","title":{"rendered":"Broken Mitochondria"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-63878\" src=\"https:\/\/www.tomgrimshaw.com\/tomsblog\/wp-content\/uploads\/2026\/03\/Broken_Mitochondria.jpg\" alt=\"Broken Mitochondria\" width=\"680\" height=\"680\" srcset=\"https:\/\/www.tomgrimshaw.com\/tomsblog\/wp-content\/uploads\/2026\/03\/Broken_Mitochondria.jpg 680w, https:\/\/www.tomgrimshaw.com\/tomsblog\/wp-content\/uploads\/2026\/03\/Broken_Mitochondria-300x300.jpg 300w, https:\/\/www.tomgrimshaw.com\/tomsblog\/wp-content\/uploads\/2026\/03\/Broken_Mitochondria-150x150.jpg 150w, https:\/\/www.tomgrimshaw.com\/tomsblog\/wp-content\/uploads\/2026\/03\/Broken_Mitochondria-100x100.jpg 100w\" sizes=\"auto, (max-width: 680px) 100vw, 680px\" \/><\/p>\n<p>Robert Lufkin MD reports on X:<\/p>\n<p>I taught medical students that insulin resistance is a mystery. It&#8217;s not. A new study in Science Advances just identified the molecular trigger &#8211; mitochondrial oxidative stress.<\/p>\n<p>Here&#8217;s what they found:<br \/>\nLipid overload floods mitochondria with reactive oxygen species<br \/>\nThis blocks GLUT4 &#8211; the glucose transporter your muscles need<br \/>\nResult: your cells can&#8217;t absorb sugar, even when insulin is screaming at them<br \/>\nTargeting mitochondrial oxidants improved insulin sensitivity by ~30%<\/p>\n<p>This is the smoking gun for Type 2 diabetes.<\/p>\n<p>We&#8217;ve spent decades blaming sugar and willpower. The real culprit is broken mitochondria &#8211; your cells&#8217; power plants drowning in metabolic waste.<\/p>\n<p>Fix the mitochondria, fix the insulin resistance. It&#8217;s that direct.<\/p>\n<p>Full breakdown coming on the Health Longevity Secrets podcast.<\/p>\n<p>Finish reading: https:\/\/www.science.org\/doi\/10.1126\/sciadv.adq4461<\/p>\n<p>(Tom: Here is my effort to provide the nutrition the body uses to repair mitochiondria: https:\/\/www.healthelicious.com.au\/NutriBlast_DNA_Heart_Mitochondria.html)<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Robert Lufkin MD reports on X: I taught medical students that insulin resistance is a mystery. It&#8217;s not. A new study in Science Advances just identified the molecular trigger &#8211; mitochondrial oxidative stress. Here&#8217;s what they found: Lipid overload floods mitochondria with reactive oxygen species This blocks GLUT4 &#8211; the glucose transporter your muscles need &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.tomgrimshaw.com\/tomsblog\/?p=63877\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Broken Mitochondria&#8221;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5,6],"tags":[],"class_list":["post-63877","post","type-post","status-publish","format-standard","hentry","category-general-interest","category-health-tips"],"_links":{"self":[{"href":"https:\/\/www.tomgrimshaw.com\/tomsblog\/index.php?rest_route=\/wp\/v2\/posts\/63877","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.tomgrimshaw.com\/tomsblog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.tomgrimshaw.com\/tomsblog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.tomgrimshaw.com\/tomsblog\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.tomgrimshaw.com\/tomsblog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=63877"}],"version-history":[{"count":1,"href":"https:\/\/www.tomgrimshaw.com\/tomsblog\/index.php?rest_route=\/wp\/v2\/posts\/63877\/revisions"}],"predecessor-version":[{"id":63879,"href":"https:\/\/www.tomgrimshaw.com\/tomsblog\/index.php?rest_route=\/wp\/v2\/posts\/63877\/revisions\/63879"}],"wp:attachment":[{"href":"https:\/\/www.tomgrimshaw.com\/tomsblog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=63877"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.tomgrimshaw.com\/tomsblog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=63877"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.tomgrimshaw.com\/tomsblog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=63877"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}