{"id":62545,"date":"2025-11-21T17:00:20","date_gmt":"2025-11-21T06:00:20","guid":{"rendered":"https:\/\/www.tomgrimshaw.com\/tomsblog\/?p=62545"},"modified":"2025-11-21T17:00:20","modified_gmt":"2025-11-21T06:00:20","slug":"revisiting-depression-dopamine-serotonin-balance-gains-attention-for-treatment-resistant-depression","status":"publish","type":"post","link":"https:\/\/www.tomgrimshaw.com\/tomsblog\/?p=62545","title":{"rendered":"Revisiting Depression \u2014 Dopamine-Serotonin Balance Gains Attention for Treatment-Resistant Depression"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-62546\" src=\"https:\/\/www.tomgrimshaw.com\/tomsblog\/wp-content\/uploads\/2025\/11\/Dopamine_Seratonin.jpg\" alt=\"Dopamine Seratonin\" width=\"372\" height=\"209\" srcset=\"https:\/\/www.tomgrimshaw.com\/tomsblog\/wp-content\/uploads\/2025\/11\/Dopamine_Seratonin.jpg 372w, https:\/\/www.tomgrimshaw.com\/tomsblog\/wp-content\/uploads\/2025\/11\/Dopamine_Seratonin-300x169.jpg 300w\" sizes=\"auto, (max-width: 372px) 100vw, 372px\" \/><\/p>\n<ul>\n<li><span id=\"bcr_rptStory_cslStory_0\">A major clinical trial in The Lancet Psychiatry found that boosting dopamine with pramipexole improved symptoms in treatment-resistant depression. This challenges the long-dominant serotonin deficiency theory<\/span><\/li>\n<li><span id=\"bcr_rptStory_cslStory_1\">Supporting those findings, another study showed that agomelatine, a serotonin-blocking drug, consistently reduced anxiety and depression in multiple placebo-controlled trials<\/span><\/li>\n<li><span id=\"bcr_rptStory_cslStory_2\">Research shows polyunsaturated and monounsaturated fats (PUFs and MUFs) directly trigger platelet aggregation and serotonin release, while saturated fats do not, linking modern diets to serotonin excess<\/span><\/li>\n<li><span id=\"bcr_rptStory_cslStory_3\">Studies confirm that combinations of unsaturated fats amplify serotonin release even at sub-threshold levels, making everyday dietary choices especially relevant to serotonin-driven health risks and mood instability<\/span><\/li>\n<li><span id=\"bcr_rptStory_cslStory_4\">Increasing GABA helps your body break down serotonin, restoring calm, better sleep, and mood stability without SSRI side effects, making it a safer alternative for addressing depression and anxiety<\/span><\/li>\n<\/ul>\n<p><a href=\"https:\/\/articles.mercola.com\/sites\/articles\/archive\/2025\/11\/10\/dopamine-serotonin-treatment-resistant-depression.aspx\">https:\/\/articles.mercola.com\/sites\/articles\/archive\/2025\/11\/10\/dopamine-serotonin-treatment-resistant-depression.aspx<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A major clinical trial in The Lancet Psychiatry found that boosting dopamine with pramipexole improved symptoms in treatment-resistant depression. This challenges the long-dominant serotonin deficiency theory Supporting those findings, another study showed that agomelatine, a serotonin-blocking drug, consistently reduced anxiety and depression in multiple placebo-controlled trials Research shows polyunsaturated and monounsaturated fats (PUFs and MUFs) &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.tomgrimshaw.com\/tomsblog\/?p=62545\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Revisiting Depression \u2014 Dopamine-Serotonin Balance Gains Attention for Treatment-Resistant Depression&#8221;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5,6],"tags":[],"class_list":["post-62545","post","type-post","status-publish","format-standard","hentry","category-general-interest","category-health-tips"],"_links":{"self":[{"href":"https:\/\/www.tomgrimshaw.com\/tomsblog\/index.php?rest_route=\/wp\/v2\/posts\/62545","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.tomgrimshaw.com\/tomsblog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.tomgrimshaw.com\/tomsblog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.tomgrimshaw.com\/tomsblog\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.tomgrimshaw.com\/tomsblog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=62545"}],"version-history":[{"count":1,"href":"https:\/\/www.tomgrimshaw.com\/tomsblog\/index.php?rest_route=\/wp\/v2\/posts\/62545\/revisions"}],"predecessor-version":[{"id":62547,"href":"https:\/\/www.tomgrimshaw.com\/tomsblog\/index.php?rest_route=\/wp\/v2\/posts\/62545\/revisions\/62547"}],"wp:attachment":[{"href":"https:\/\/www.tomgrimshaw.com\/tomsblog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=62545"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.tomgrimshaw.com\/tomsblog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=62545"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.tomgrimshaw.com\/tomsblog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=62545"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}