{"id":62161,"date":"2025-10-18T15:28:13","date_gmt":"2025-10-18T04:28:13","guid":{"rendered":"https:\/\/www.tomgrimshaw.com\/tomsblog\/?p=62161"},"modified":"2025-10-18T15:28:13","modified_gmt":"2025-10-18T04:28:13","slug":"blockbuster-anticlotting-drug-approved-on-flawed-studies","status":"publish","type":"post","link":"https:\/\/www.tomgrimshaw.com\/tomsblog\/?p=62161","title":{"rendered":"Blockbuster Anticlotting Drug Approved on Flawed Studies"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-62162\" src=\"https:\/\/www.tomgrimshaw.com\/tomsblog\/wp-content\/uploads\/2025\/10\/Time_To_Rethink.jpg\" alt=\"Time To Rethink\" width=\"920\" height=\"516\" srcset=\"https:\/\/www.tomgrimshaw.com\/tomsblog\/wp-content\/uploads\/2025\/10\/Time_To_Rethink.jpg 920w, https:\/\/www.tomgrimshaw.com\/tomsblog\/wp-content\/uploads\/2025\/10\/Time_To_Rethink-300x168.jpg 300w, https:\/\/www.tomgrimshaw.com\/tomsblog\/wp-content\/uploads\/2025\/10\/Time_To_Rethink-768x431.jpg 768w\" sizes=\"auto, (max-width: 767px) 89vw, (max-width: 1000px) 54vw, (max-width: 1071px) 543px, 580px\" \/><\/p>\n<ul>\n<li><span id=\"bcr_rptStory_cslStory_0\">Ticagrelor, a blockbuster anticlotting drug, was approved despite FDA scientists warning it looked less safe and effective than older, cheaper alternatives like clopidogrel<\/span><\/li>\n<li><span id=\"bcr_rptStory_cslStory_1\">The landmark PLATO trial used to secure approval showed U.S. patients had worse outcomes on ticagrelor, yet those results were overridden by FDA leadership<\/span><\/li>\n<li><span id=\"bcr_rptStory_cslStory_2\">Investigations revealed serious problems with the trial, including altered death records, missing data, and inconsistent monitoring that favored ticagrelor<\/span><\/li>\n<li><span id=\"bcr_rptStory_cslStory_3\">Follow-up platelet studies were also misreported, with non-significant results published as significant and some listed authors denying participation<\/span><\/li>\n<li><span id=\"bcr_rptStory_cslStory_4\">Knowing these flaws allows you to ask about proven alternatives, reduce your personal heart risk through lifestyle, and avoid dependence on drugs pushed forward with weak, flawed evidence<\/span><\/li>\n<\/ul>\n<p><a href=\"https:\/\/articles.mercola.com\/sites\/articles\/archive\/2025\/10\/16\/ticagrelor-brilinta-fda-approval-flawed-studies.aspx\">https:\/\/articles.mercola.com\/sites\/articles\/archive\/2025\/10\/16\/ticagrelor-brilinta-fda-approval-flawed-studies.aspx<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ticagrelor, a blockbuster anticlotting drug, was approved despite FDA scientists warning it looked less safe and effective than older, cheaper alternatives like clopidogrel The landmark PLATO trial used to secure approval showed U.S. patients had worse outcomes on ticagrelor, yet those results were overridden by FDA leadership Investigations revealed serious problems with the trial, including &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.tomgrimshaw.com\/tomsblog\/?p=62161\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Blockbuster Anticlotting Drug Approved on Flawed Studies&#8221;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5,6],"tags":[],"class_list":["post-62161","post","type-post","status-publish","format-standard","hentry","category-general-interest","category-health-tips"],"_links":{"self":[{"href":"https:\/\/www.tomgrimshaw.com\/tomsblog\/index.php?rest_route=\/wp\/v2\/posts\/62161","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.tomgrimshaw.com\/tomsblog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.tomgrimshaw.com\/tomsblog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.tomgrimshaw.com\/tomsblog\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.tomgrimshaw.com\/tomsblog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=62161"}],"version-history":[{"count":1,"href":"https:\/\/www.tomgrimshaw.com\/tomsblog\/index.php?rest_route=\/wp\/v2\/posts\/62161\/revisions"}],"predecessor-version":[{"id":62163,"href":"https:\/\/www.tomgrimshaw.com\/tomsblog\/index.php?rest_route=\/wp\/v2\/posts\/62161\/revisions\/62163"}],"wp:attachment":[{"href":"https:\/\/www.tomgrimshaw.com\/tomsblog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=62161"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.tomgrimshaw.com\/tomsblog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=62161"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.tomgrimshaw.com\/tomsblog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=62161"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}