{"id":42748,"date":"2023-01-05T15:38:13","date_gmt":"2023-01-05T04:38:13","guid":{"rendered":"https:\/\/www.tomgrimshaw.com\/tomsblog\/?p=42748"},"modified":"2023-01-05T15:38:13","modified_gmt":"2023-01-05T04:38:13","slug":"massive-discovery-known-in-2007-expressing-the-viral-spike-protein-alone-induces-endoplasmic-reticulum-stress-an-explanation-for-emerging-heterogeneous-pathologies","status":"publish","type":"post","link":"https:\/\/www.tomgrimshaw.com\/tomsblog\/?p=42748","title":{"rendered":"MASSIVE DISCOVERY: Known in 2007: EXPRESSING THE VIRAL SPIKE PROTEIN ALONE Induces Endoplasmic Reticulum Stress: An Explanation for Emerging Heterogeneous Pathologies"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone  wp-image-42749\" src=\"http:\/\/www.tomgrimshaw.com\/tomsblog\/wp-content\/uploads\/2023\/01\/ER_Stress-300x186.jpg\" alt=\"ER Stress\" width=\"1044\" height=\"647\" srcset=\"https:\/\/www.tomgrimshaw.com\/tomsblog\/wp-content\/uploads\/2023\/01\/ER_Stress-300x186.jpg 300w, https:\/\/www.tomgrimshaw.com\/tomsblog\/wp-content\/uploads\/2023\/01\/ER_Stress.jpg 734w\" sizes=\"auto, (max-width: 767px) 89vw, (max-width: 1000px) 54vw, (max-width: 1071px) 543px, 580px\" \/><\/p>\n<p>I believe we now have a cornerstone piece of the puzzle as to why SARS-CoV-2 and its Spike Protein induce such a wide array of pathologies. The Spike Protein causes massive Endoplasmic Reticulum (ER) stress and, depending upon the individual, this can manifest in a wide range of diseases.<\/p>\n<p>What astounds me is that this was known in 2007.<\/p>\n<blockquote><p><strong>Expression of the viral spike protein significantly induced ER stress<\/strong>\u00a0and Cxcl2 mRNA upregulation,\u00a0<em><strong>while expression of the other structural genes did not<\/strong><\/em>.<\/p><\/blockquote>\n<p><strong>The coronavirus spike protein induces endoplasmic reticulum stress and upregulation of intracellular chemokine mRNA concentrations<\/strong><br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17670839\/\" rel=\"\">https:\/\/pubmed.ncbi.nlm.nih.gov\/17670839\/<\/a><\/p>\n<p>Please understand the finding. EXPRESSION of Spike Protein. This means that if your cells EXPRESS the Spike Protein, it causes ER stress. I leave it to the reader to do the math.<\/p>\n<p>ER stress can induce Diabetes, Neurodegeneration, Cancer and PRION FORMATION.<\/p>\n<p><strong>Endoplasmic Reticulum Stress in Disease Pathogenesis<\/strong><br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3653419\/\" rel=\"\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3653419\/<\/a><\/p>\n<p><strong>ER stress causes widespread protein aggregation and prion formation<\/strong><br \/>\n<a href=\"https:\/\/rupress.org\/jcb\/article\/216\/8\/2295\/39185\/ER-stress-causes-widespread-protein-aggregation\" rel=\"\">https:\/\/rupress.org\/jcb\/article\/216\/8\/2295\/39185\/ER-stress-causes-widespread-protein-aggregation<\/a><\/p>\n<p>I will continue to work on the implications of this finding.<\/p>\n<p>The cat is really out of the bag now\u2026<\/p>\n<p><a href=\"https:\/\/wmcresearch.substack.com\/p\/massive-discovery-known-in-2007-expressing\">https:\/\/wmcresearch.substack.com\/p\/massive-discovery-known-in-2007-expressing<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>I believe we now have a cornerstone piece of the puzzle as to why SARS-CoV-2 and its Spike Protein induce such a wide array of pathologies. The Spike Protein causes massive Endoplasmic Reticulum (ER) stress and, depending upon the individual, this can manifest in a wide range of diseases. What astounds me is that this &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.tomgrimshaw.com\/tomsblog\/?p=42748\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;MASSIVE DISCOVERY: Known in 2007: EXPRESSING THE VIRAL SPIKE PROTEIN ALONE Induces Endoplasmic Reticulum Stress: An Explanation for Emerging Heterogeneous Pathologies&#8221;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5,6,133],"tags":[],"class_list":["post-42748","post","type-post","status-publish","format-standard","hentry","category-general-interest","category-health-tips","category-vaccines"],"_links":{"self":[{"href":"https:\/\/www.tomgrimshaw.com\/tomsblog\/index.php?rest_route=\/wp\/v2\/posts\/42748","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.tomgrimshaw.com\/tomsblog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.tomgrimshaw.com\/tomsblog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.tomgrimshaw.com\/tomsblog\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.tomgrimshaw.com\/tomsblog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=42748"}],"version-history":[{"count":1,"href":"https:\/\/www.tomgrimshaw.com\/tomsblog\/index.php?rest_route=\/wp\/v2\/posts\/42748\/revisions"}],"predecessor-version":[{"id":42750,"href":"https:\/\/www.tomgrimshaw.com\/tomsblog\/index.php?rest_route=\/wp\/v2\/posts\/42748\/revisions\/42750"}],"wp:attachment":[{"href":"https:\/\/www.tomgrimshaw.com\/tomsblog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=42748"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.tomgrimshaw.com\/tomsblog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=42748"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.tomgrimshaw.com\/tomsblog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=42748"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}